Real time monitoring of the polymerisation of PMMA bone cement using Raman spectroscopy

Christopher P. Hagan; John F. Orr; Christina A. Mitchell; Nicholas J. Dunne

doi:10.1007/s10856-009-3822-1

Real time monitoring of the polymerisation of PMMA bone cement using Raman spectroscopy

Christopher P. Hagan, John F. Orr, Christina A. Mitchell, Nicholas J. Dunne

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

In this investigation Raman spectroscopy was shown to be a method that could be used to monitor the polymerisation of PMMA bone cement. Presently there is no objective method that orthopaedic surgeons can use to quantify the curing process of cement during surgery. Raman spectroscopy is a non-invasive, non-destructive technique that could offer such an option. Two commercially available bone cements (Palacos® R and SmartSet® HV) and different storage conditions (4 and 22°C) were used to validate the technique. Raman spectroscopy was found to be repeatable across all conditions with the completion of the polymerisation process particularly easy to establish. All tests were benchmarked against current temperature monitoring methods outlined in ISO and ASTM standards. There was found to be close agreement with the standard methods and the Raman spectroscopy used in this study.

Original language	English
Pages (from-to)	2427-2433
Number of pages	7
Journal	Journal of Materials Science: Materials in Medicine
Volume	20
Issue number	12
DOIs	https://doi.org/10.1007/s10856-009-3822-1
Publication status	Published - Dec 2009

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title = "Real time monitoring of the polymerisation of PMMA bone cement using Raman spectroscopy",

abstract = "In this investigation Raman spectroscopy was shown to be a method that could be used to monitor the polymerisation of PMMA bone cement. Presently there is no objective method that orthopaedic surgeons can use to quantify the curing process of cement during surgery. Raman spectroscopy is a non-invasive, non-destructive technique that could offer such an option. Two commercially available bone cements (Palacos{\textregistered} R and SmartSet{\textregistered} HV) and different storage conditions (4 and 22°C) were used to validate the technique. Raman spectroscopy was found to be repeatable across all conditions with the completion of the polymerisation process particularly easy to establish. All tests were benchmarked against current temperature monitoring methods outlined in ISO and ASTM standards. There was found to be close agreement with the standard methods and the Raman spectroscopy used in this study.",

author = "Hagan, {Christopher P.} and Orr, {John F.} and Mitchell, {Christina A.} and Dunne, {Nicholas J.}",

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T1 - Real time monitoring of the polymerisation of PMMA bone cement using Raman spectroscopy

AU - Hagan, Christopher P.

AU - Orr, John F.

AU - Mitchell, Christina A.

AU - Dunne, Nicholas J.

PY - 2009/12

Y1 - 2009/12

N2 - In this investigation Raman spectroscopy was shown to be a method that could be used to monitor the polymerisation of PMMA bone cement. Presently there is no objective method that orthopaedic surgeons can use to quantify the curing process of cement during surgery. Raman spectroscopy is a non-invasive, non-destructive technique that could offer such an option. Two commercially available bone cements (Palacos® R and SmartSet® HV) and different storage conditions (4 and 22°C) were used to validate the technique. Raman spectroscopy was found to be repeatable across all conditions with the completion of the polymerisation process particularly easy to establish. All tests were benchmarked against current temperature monitoring methods outlined in ISO and ASTM standards. There was found to be close agreement with the standard methods and the Raman spectroscopy used in this study.

AB - In this investigation Raman spectroscopy was shown to be a method that could be used to monitor the polymerisation of PMMA bone cement. Presently there is no objective method that orthopaedic surgeons can use to quantify the curing process of cement during surgery. Raman spectroscopy is a non-invasive, non-destructive technique that could offer such an option. Two commercially available bone cements (Palacos® R and SmartSet® HV) and different storage conditions (4 and 22°C) were used to validate the technique. Raman spectroscopy was found to be repeatable across all conditions with the completion of the polymerisation process particularly easy to establish. All tests were benchmarked against current temperature monitoring methods outlined in ISO and ASTM standards. There was found to be close agreement with the standard methods and the Raman spectroscopy used in this study.

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SP - 2427

EP - 2433

JO - Journal of Materials Science: Materials in Medicine

JF - Journal of Materials Science: Materials in Medicine

IS - 12

ER -

Real time monitoring of the polymerisation of PMMA bone cement using Raman spectroscopy

Abstract

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