Reasons to Be Nervous about Flukicide Discovery

Paul McVeigh, Paul McCusker, Emily Robb, Duncan Wells, Erica Gardiner, Angela Mousley, Nikki J. Marks, Aaron G. Maule*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


The majority of anthelmintics dysregulate neuromuscular function, a fact most prominent for drugs against nematode parasites. In contrast to the strong knowledge base for nematode neurobiology, resource and tool deficits have prevented similar advances in flatworm parasites since those driven by bioimaging, immunocytochemistry, and neuropeptide biochemistry 20-30 years ago. However, recent developments are encouraging a renaissance in liver fluke neurobiology that can now support flukicide discovery. Emerging data promote neuromuscular signalling components, and especially G protein-coupled receptors (GPCRs), as next-generation targets. Here, we summarise these data and expose some of the new opportunities to accelerate progress towards GPCR-targeted flukicides for Fasciola hepatica.

Original languageEnglish
Pages (from-to)184-196
Number of pages13
JournalTrends in Parasitology
Issue number3
Early online date18 Dec 2017
Publication statusPublished - 01 Mar 2018

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases


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