Reasons to Be Nervous about Flukicide Discovery

Paul McVeigh; Paul McCusker; Emily Robb; Duncan Wells; Erica Gardiner; Angela Mousley; Nikki J. Marks; Aaron G. Maule

doi:10.1016/j.pt.2017.11.010

Reasons to Be Nervous about Flukicide Discovery

Paul McVeigh, Paul McCusker, Emily Robb, Duncan Wells, Erica Gardiner, Angela Mousley, Nikki J. Marks, Aaron G. Maule^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The majority of anthelmintics dysregulate neuromuscular function, a fact most prominent for drugs against nematode parasites. In contrast to the strong knowledge base for nematode neurobiology, resource and tool deficits have prevented similar advances in flatworm parasites since those driven by bioimaging, immunocytochemistry, and neuropeptide biochemistry 20-30 years ago. However, recent developments are encouraging a renaissance in liver fluke neurobiology that can now support flukicide discovery. Emerging data promote neuromuscular signalling components, and especially G protein-coupled receptors (GPCRs), as next-generation targets. Here, we summarise these data and expose some of the new opportunities to accelerate progress towards GPCR-targeted flukicides for Fasciola hepatica.

Original language	English
Pages (from-to)	184-196
Number of pages	13
Journal	Trends in Parasitology
Volume	34
Issue number	3
Early online date	18 Dec 2017
DOIs	https://doi.org/10.1016/j.pt.2017.11.010
Publication status	Published - 01 Mar 2018

ASJC Scopus subject areas

Parasitology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.pt.2017.11.010Licence: Unspecified

Cite this

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title = "Reasons to Be Nervous about Flukicide Discovery",

abstract = "The majority of anthelmintics dysregulate neuromuscular function, a fact most prominent for drugs against nematode parasites. In contrast to the strong knowledge base for nematode neurobiology, resource and tool deficits have prevented similar advances in flatworm parasites since those driven by bioimaging, immunocytochemistry, and neuropeptide biochemistry 20-30 years ago. However, recent developments are encouraging a renaissance in liver fluke neurobiology that can now support flukicide discovery. Emerging data promote neuromuscular signalling components, and especially G protein-coupled receptors (GPCRs), as next-generation targets. Here, we summarise these data and expose some of the new opportunities to accelerate progress towards GPCR-targeted flukicides for Fasciola hepatica.",

author = "Paul McVeigh and Paul McCusker and Emily Robb and Duncan Wells and Erica Gardiner and Angela Mousley and Marks, {Nikki J.} and Maule, {Aaron G.}",

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T1 - Reasons to Be Nervous about Flukicide Discovery

AU - McVeigh, Paul

AU - McCusker, Paul

AU - Robb, Emily

AU - Wells, Duncan

AU - Gardiner, Erica

AU - Mousley, Angela

AU - Marks, Nikki J.

AU - Maule, Aaron G.

PY - 2018/3/1

Y1 - 2018/3/1

N2 - The majority of anthelmintics dysregulate neuromuscular function, a fact most prominent for drugs against nematode parasites. In contrast to the strong knowledge base for nematode neurobiology, resource and tool deficits have prevented similar advances in flatworm parasites since those driven by bioimaging, immunocytochemistry, and neuropeptide biochemistry 20-30 years ago. However, recent developments are encouraging a renaissance in liver fluke neurobiology that can now support flukicide discovery. Emerging data promote neuromuscular signalling components, and especially G protein-coupled receptors (GPCRs), as next-generation targets. Here, we summarise these data and expose some of the new opportunities to accelerate progress towards GPCR-targeted flukicides for Fasciola hepatica.

AB - The majority of anthelmintics dysregulate neuromuscular function, a fact most prominent for drugs against nematode parasites. In contrast to the strong knowledge base for nematode neurobiology, resource and tool deficits have prevented similar advances in flatworm parasites since those driven by bioimaging, immunocytochemistry, and neuropeptide biochemistry 20-30 years ago. However, recent developments are encouraging a renaissance in liver fluke neurobiology that can now support flukicide discovery. Emerging data promote neuromuscular signalling components, and especially G protein-coupled receptors (GPCRs), as next-generation targets. Here, we summarise these data and expose some of the new opportunities to accelerate progress towards GPCR-targeted flukicides for Fasciola hepatica.

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U2 - 10.1016/j.pt.2017.11.010

DO - 10.1016/j.pt.2017.11.010

M3 - Article

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JO - Trends in Parasitology

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Reasons to Be Nervous about Flukicide Discovery

Abstract

ASJC Scopus subject areas

UN SDGs

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Other files and links

Fingerprint

Liver fluke development: A target for parasite control?

Post-genomic studies on the neuropeptide signalling system of Juvenile Fasciola hepatica

Cite this

Reasons to Be Nervous about Flukicide Discovery

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Student theses

Liver fluke development: A target for parasite control?

Post-genomic studies on the neuropeptide signalling system of Juvenile Fasciola hepatica

Cite this