Recent advances in NIR-II fluorescence based theranostic approaches for glioma

Jiaying Li, Jue Ling, Chaoyi Yao

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3 Citations (Scopus)
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Gliomas are among the most common malignant tumors in the central nervous system and lead to poor life expectancy. However, the effective treatment of gliomas remains a considerable challenge. The recent development of near infrared (NIR) II (1000-1700 nm) theranostic agents has led to powerful strategies in diagnosis, targeted delivery of drugs, and accurate therapy. Because of the high capacity of NIR-II light in deep tissue penetration, improved spatiotemporal resolution can be achieved to facilitate the detection of gliomas fluorescence imaging, and high contrast fluorescence imaging guided surgery can be realized. In addition to the precise imaging of tumors, drug delivery nano-platforms with NIR-II agents also allow the delivery process to be monitored in real-time. In addition, the combination of targeted drug delivery, photodynamic therapy, and photothermal therapy in the NIR region significantly improves the therapeutic effect against gliomas. Thus, this mini-review summarizes the recent developments in NIR-II fluorescence-based theranostic agents for glioma treatment. [Abstract copyright: Copyright © 2022 Li, Ling and Yao.]
Original languageEnglish
Article number1054913
Number of pages7
JournalFrontiers in Chemistry
Early online date04 Nov 2022
Publication statusEarly online date - 04 Nov 2022


  • photodynamic therapy
  • NIR dyes
  • photothermal therapy
  • fluorescence imaging
  • glioma
  • delivery system


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