Recent applications of Chemical Imaging to pharmaceutical process monitoring and quality control

A.A. Gowen, C.P. O'Donnell, P.J. Cullen, Steven Bell

Research output: Contribution to journalArticlepeer-review

223 Citations (Scopus)

Abstract

Chemical Imaging (CI) is an emerging platform technology that integrates conventional imaging and spectroscopy to attain both spatial and spectral information from an object. Vibrational spectroscopic methods, such as Near Infrared (NIR) and Raman spectroscopy, combined with imaging are particularly useful for analysis of biological/pharmaceutical forms. The rapid, non-destructive and non-invasive features of CI mark its potential suitability as a process analytical tool for the pharmaceutical industry, for both process monitoring and quality control in the many stages of drug production. This paper provides an overview of CI principles, instrumentation and analysis. Recent applications of Raman and NIR-CI to pharmaceutical quality and process control are presented; challenges facing Cl implementation and likely future developments in the technology are also discussed. (C) 2007 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)10-22
Number of pages13
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
Volume69 (1)
Issue number1
DOIs
Publication statusPublished - May 2008

ASJC Scopus subject areas

  • Biotechnology
  • Pharmaceutical Science

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