Recent mumps outbreaks in vaccinated populations: no evidence of immune escape.

Steven Rubin, Malen A. Link, Christian J. Sauder, Cheryl Zhang, Laurie Ngo, Bert Rima, Paul Duprex

Research output: Contribution to journalArticle

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Abstract

Recently, numerous large-scale mumps outbreaks have occurred in vaccinated populations. Clinical isolates sequenced from these outbreaks have invariably been of genotypes distinct from those of vaccine viruses, raising concern that certain mumps virus strains may escape vaccine-induced immunity. To investigate this concern, sera obtained from children 6 weeks after receipt of measles, mumps, and rubella (MMR) vaccine were tested for the ability to neutralize a carefully selected group of genetically diverse mumps virus strains. Although the geometric mean neutralizing antibody titer of the sera was lower against some virus strains than others, all viruses were readily neutralized, arguing against immune escape.
Original languageEnglish
Pages (from-to)615-620
Number of pages6
JournalJournal of Virology
Volume86
Issue number1
Early online date09 Nov 2011
DOIs
Publication statusPublished - Jan 2012

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Mumps
Mumps virus
Disease Outbreaks
vaccines
Viruses
viruses
Vaccines
Measles-Mumps-Rubella Vaccine
Population
Neutralizing Antibodies
Serum
neutralizing antibodies
Immunity
immunity
Genotype
genotype

Cite this

Rubin, S., Link, M. A., Sauder, C. J., Zhang, C., Ngo, L., Rima, B., & Duprex, P. (2012). Recent mumps outbreaks in vaccinated populations: no evidence of immune escape. Journal of Virology, 86(1), 615-620. https://doi.org/10.1128/JVI.06125-11
Rubin, Steven ; Link, Malen A. ; Sauder, Christian J. ; Zhang, Cheryl ; Ngo, Laurie ; Rima, Bert ; Duprex, Paul. / Recent mumps outbreaks in vaccinated populations: no evidence of immune escape. In: Journal of Virology. 2012 ; Vol. 86, No. 1. pp. 615-620.
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Rubin, S, Link, MA, Sauder, CJ, Zhang, C, Ngo, L, Rima, B & Duprex, P 2012, 'Recent mumps outbreaks in vaccinated populations: no evidence of immune escape.', Journal of Virology, vol. 86, no. 1, pp. 615-620. https://doi.org/10.1128/JVI.06125-11

Recent mumps outbreaks in vaccinated populations: no evidence of immune escape. / Rubin, Steven; Link, Malen A.; Sauder, Christian J.; Zhang, Cheryl; Ngo, Laurie; Rima, Bert; Duprex, Paul.

In: Journal of Virology, Vol. 86, No. 1, 01.2012, p. 615-620.

Research output: Contribution to journalArticle

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