Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 615-620 |
| Number of pages | 6 |
| Journal | Journal of Virology |
| Volume | 86 |
| Issue number | 1 |
| Early online date | 09 Nov 2011 |
| DOIs | |
| Publication status | Published - Jan 2012 |
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Recent mumps outbreaks in vaccinated populations: no evidence of immune escape. / Rubin, Steven; Link, Malen A.; Sauder, Christian J.; Zhang, Cheryl; Ngo, Laurie; Rima, Bert; Duprex, Paul.
In: Journal of Virology, Vol. 86, No. 1, 01.2012, p. 615-620.Research output: Contribution to journal › Article
TY - JOUR
T1 - Recent mumps outbreaks in vaccinated populations: no evidence of immune escape.
AU - Rubin, Steven
AU - Link, Malen A.
AU - Sauder, Christian J.
AU - Zhang, Cheryl
AU - Ngo, Laurie
AU - Rima, Bert
AU - Duprex, Paul
PY - 2012/1
Y1 - 2012/1
N2 - Recently, numerous large-scale mumps outbreaks have occurred in vaccinated populations. Clinical isolates sequenced from these outbreaks have invariably been of genotypes distinct from those of vaccine viruses, raising concern that certain mumps virus strains may escape vaccine-induced immunity. To investigate this concern, sera obtained from children 6 weeks after receipt of measles, mumps, and rubella (MMR) vaccine were tested for the ability to neutralize a carefully selected group of genetically diverse mumps virus strains. Although the geometric mean neutralizing antibody titer of the sera was lower against some virus strains than others, all viruses were readily neutralized, arguing against immune escape.
AB - Recently, numerous large-scale mumps outbreaks have occurred in vaccinated populations. Clinical isolates sequenced from these outbreaks have invariably been of genotypes distinct from those of vaccine viruses, raising concern that certain mumps virus strains may escape vaccine-induced immunity. To investigate this concern, sera obtained from children 6 weeks after receipt of measles, mumps, and rubella (MMR) vaccine were tested for the ability to neutralize a carefully selected group of genetically diverse mumps virus strains. Although the geometric mean neutralizing antibody titer of the sera was lower against some virus strains than others, all viruses were readily neutralized, arguing against immune escape.
U2 - 10.1128/JVI.06125-11
DO - 10.1128/JVI.06125-11
M3 - Article
C2 - 22072778
VL - 86
SP - 615
EP - 620
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 1
ER -