Recombinant alpha 2(IV)NC1 domain of type IV collagen is an effective regulator of retinal capillary endothelial cell proliferation and inhibits pre-retinal neovascularisation

Gary Coleman, Tom Gardiner, A. Boutaud, Alan Stitt

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Background A recombinant form of the alpha 2(IV)NC1 domain of type IV collagen has been shown to have potent anti-angiogenic activity although this peptide has not been studied in the context of proliferative retinopathies. In the current investigation we examined the potential for alpha 2(IV) NC1 to regulate retinal microvascular endothelial cell function using a range of in vitro and in vivo assay systems.
Original languageEnglish
Pages (from-to)581-587
Number of pages7
JournalGraefes Archive for Clinical and Experimental Ophthalmology
Volume245
Issue number4
DOIs
Publication statusPublished - Apr 2007

ASJC Scopus subject areas

  • Ophthalmology

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