Recommendations for standardizing nomenclature for dietary(poly)phenol catabolites: Nomenclature for (poly)phenol catabolites

Colin D. Kay, Michael N. Clifford, Gordon J McDougall, Pedro Mena, Cristina Andres-Lacueva, Aedin Cassidy, Daniele Del Rio, Nikolai Kuhnert, Claudine Manach, Gema Pereira-Caro, Ana Rodriguez-Mateos, Augustin Scalbert, Francisco Tomás-Barberán, Gary Williamson, David S Wishart, Alan Crozier

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)
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Abstract

There is a lack of focus on the protective health effects of phytochemicals in dietary guidelines. While a number of chemical libraries and databases contain dietary phytochemicals belonging to the plant metabolome, they are not entirely relevant to human health as many constituents are extensively metabolized within the body following ingestion. This is especially apparent for the highly abundant dietary (poly)phenols, where the situation is compounded by confusion regarding their bioavailability and metabolism, partially because of the variety of nomenclatures and trivial names used to describe compounds arising from microbial catabolism in the gastrointestinal tract. This confusion, which is perpetuated in online chemical/metabolite databases, will hinder future discovery of bioactivities and affect the establishment of future dietary guidelines if steps are not taken to overcome these issues. In order to resolve this situation, a nomenclature system for phenolic catabolites and their human phase II metabolites is proposed and the basis of its format outlined. Previous names used in the literature are cited along with the recommended nomenclature, IUPAC terminology and, where appropriate, CAS numbers, InChIKey, and accurate mass.
Original languageEnglish
Pages (from-to)1051–1068
Number of pages18
JournalThe American journal of clinical nutrition
Volume112
Issue number4
Early online date16 Sep 2020
DOIs
Publication statusPublished - Oct 2020

Keywords

  • Dietary (poly)phenols Microbial catabolites/metabolites Nomenclature Food/diet metabolome

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