Recurrence of Philadelphia chromosome-positive leukemia in donor cells after bone marrow transplantation for chronic granulocytic leukemia

S R McCann, M Lawler, A Bacigalupo, Mark Lawler

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Allogeneic bone marrow transplantation has been shown to be a very effective therapy for Chronic Granulocytic Leukemia with long term disease free survivals in excess of 60%. Relapse rates remain low at 15% following histocompatible sibling transplants and lower rates following matched unrelated donor grafts. Relapse rates however, are higher if BMT is carried out in transformation or blast crisis. Leukemic relapse in donor cells following transplantation for CGL is a rare event. The occurrence of donor leukemia however, may be under reported as accurate and sensitive investigation of the origin of relapsed leukemia following BMT requires DNA based technologies. A possible mechanism of donor leukemia in CGL is transfection of donor cells with the chimeric gene which is unique to this disease. It is possible that the malignant cells found in transformed or blast crisis of CGL may have a greater potential to transfect donor haematopoietic material. Careful evaluation of the incidence of donor leukemia using molecular biology methods may elucidate the frequency of this event following BMT for CGL.

Original languageEnglish
Pages (from-to)419-25
Number of pages7
JournalLeukemia & lymphoma
Volume10
Issue number6
DOIs
Publication statusPublished - Aug 1993

Keywords

  • Animals
  • Bone Marrow Transplantation
  • Cell Transformation, Neoplastic
  • Humans
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • Philadelphia Chromosome
  • Recurrence
  • Transfection

Fingerprint Dive into the research topics of 'Recurrence of Philadelphia chromosome-positive leukemia in donor cells after bone marrow transplantation for chronic granulocytic leukemia'. Together they form a unique fingerprint.

  • Cite this