Red blood cell fatty acids and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Jakob Linseisen; Nina Grundmann; Dorothee Zoller; Tilman Kuehn; Eugene H J M Jansen; Veronique Chajes; Veronika Fedirko; Elisabete Weiderpass; Christina C Dahm; Kim Overvad; Anne Tjonneland; Marie-Christine Boutron-Ruault; Joseph A Rothwell; Gianluca Severi; Rudolf Kaaks; Matthias B Schulze; Krasimira Aleksandrova; Sabina Sieri; Salvatore Panico; Rosario Tumino; Giovanna Masala; Laura De Marco; Bas Bueno-de-Mesquita; Roel Vermeulen; Inger T Gram; Guri Skeie; Maria-Dolores Chirlaque; Eva Ardanaz; Antonio Agudo; Maria-Jose Sánchez; Pilar Amiano; Maria Wennberg; Stina Bodén; Aurora Perez-Cornago; Elom Kouassivi Aglago; Marc J Gunter; Mazda Jenab; Alicia K Heath; Alexandra Nieters

doi:10.1158/1055-9965.EPI-20-1426

Red blood cell fatty acids and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Jakob Linseisen, Nina Grundmann, Dorothee Zoller, Tilman Kuehn, Eugene H J M Jansen, Veronique Chajes, Veronika Fedirko, Elisabete Weiderpass, Christina C Dahm, Kim Overvad, Anne Tjonneland, Marie-Christine Boutron-Ruault, Joseph A Rothwell, Gianluca Severi, Rudolf Kaaks, Matthias B Schulze, Krasimira Aleksandrova, Sabina Sieri, Salvatore Panico, Rosario TuminoGiovanna Masala, Laura De Marco, Bas Bueno-de-Mesquita, Roel Vermeulen, Inger T Gram, Guri Skeie, Maria-Dolores Chirlaque, Eva Ardanaz, Antonio Agudo, Maria-Jose Sánchez, Pilar Amiano, Maria Wennberg, Stina Bodén, Aurora Perez-Cornago, Elom Kouassivi Aglago, Marc J Gunter, Mazda Jenab, Alicia K Heath, Alexandra Nieters

Research output: Contribution to journal › Article › peer-review

8 Downloads (Pure)

Abstract

BACKGROUND: A growing body of evidence suggests that alterations of dietary fatty acid (FA) profiles are associated with colorectal cancer (CRC) risk. However, data from large-scale epidemiological studies using circulating FA measurements to objectively assess individual FA and FA categories are scarce.

METHODS: To investigate the association between red blood cell (RBC) membrane FAs and risk of CRC in a case-control study nested within a large prospective cohort. After a median follow-up of 6.4 years, 1069 incident CRC cases were identified and matched to 1069 controls among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). The FA composition of RBC phospholipids (in mol%) was analyzed by gas chromatography, and their association with risk of CRC was estimated by multivariable adjusted conditional logistic regression models.

RESULTS: After correction for multiple testing, subjects with higher concentrations of RBC stearic acid were at higher risk for CRC (OR=1.23; 95% CI=1.07-1.42, per 1 mol%). Conversely, CRC incidence decreased with increasing proportions of RBC n-3 PUFA, particularly eicosapentaenoic acid (0.75; 0.62-0.92, per 1 mol%). The findings for the n-6 PUFA arachidonic acid were inconsistent.

CONCLUSIONS: The positive association between pre-diagnostic RBC stearic acid and CRC reflects putative differences in FA intake and metabolism between cancer cases and matched controls which deserve further investigation. The inverse relationship between EPA and CRC is in line with the repeatedly reported protective effect of fish consumption on CRC risk.

IMPACT: These findings add to the evidence on CRC prevention.

Original language	English
Journal	Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Early online date	22 Feb 2021
DOIs	https://doi.org/10.1158/1055-9965.EPI-20-1426
Publication status	Early online date - 22 Feb 2021
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1158/1055-9965.EPI-20-1426Licence: Unspecified

Red blood cell fatty acids and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC).
Copyright 2021, American Association for Cancer Research. This work is made available online in accordance with the publisher’s policies. Please refer to any applicable terms of use of the publisher.
Accepted author manuscript, 592 KBLicence: Unspecified

Cite this

Linseisen, J., Grundmann, N., Zoller, D., Kuehn, T., Jansen, E. H. J. M., Chajes, V., Fedirko, V., Weiderpass, E., Dahm, C. C., Overvad, K., Tjonneland, A., Boutron-Ruault, M-C., Rothwell, J. A., Severi, G., Kaaks, R., Schulze, M. B., Aleksandrova, K., Sieri, S., Panico, S., ... Nieters, A. (2021). Red blood cell fatty acids and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. https://doi.org/10.1158/1055-9965.EPI-20-1426

Linseisen, Jakob ; Grundmann, Nina ; Zoller, Dorothee ; Kuehn, Tilman ; Jansen, Eugene H J M ; Chajes, Veronique ; Fedirko, Veronika ; Weiderpass, Elisabete ; Dahm, Christina C ; Overvad, Kim ; Tjonneland, Anne ; Boutron-Ruault, Marie-Christine ; Rothwell, Joseph A ; Severi, Gianluca ; Kaaks, Rudolf ; Schulze, Matthias B ; Aleksandrova, Krasimira ; Sieri, Sabina ; Panico, Salvatore ; Tumino, Rosario ; Masala, Giovanna ; De Marco, Laura ; Bueno-de-Mesquita, Bas ; Vermeulen, Roel ; Gram, Inger T ; Skeie, Guri ; Chirlaque, Maria-Dolores ; Ardanaz, Eva ; Agudo, Antonio ; Sánchez, Maria-Jose ; Amiano, Pilar ; Wennberg, Maria ; Bodén, Stina ; Perez-Cornago, Aurora ; Aglago, Elom Kouassivi ; Gunter, Marc J ; Jenab, Mazda ; Heath, Alicia K ; Nieters, Alexandra. / Red blood cell fatty acids and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). In: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2021.

@article{583ee8a43f22404c9bc6257a824e6e56,

title = "Red blood cell fatty acids and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)",

abstract = "BACKGROUND: A growing body of evidence suggests that alterations of dietary fatty acid (FA) profiles are associated with colorectal cancer (CRC) risk. However, data from large-scale epidemiological studies using circulating FA measurements to objectively assess individual FA and FA categories are scarce.METHODS: To investigate the association between red blood cell (RBC) membrane FAs and risk of CRC in a case-control study nested within a large prospective cohort. After a median follow-up of 6.4 years, 1069 incident CRC cases were identified and matched to 1069 controls among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). The FA composition of RBC phospholipids (in mol%) was analyzed by gas chromatography, and their association with risk of CRC was estimated by multivariable adjusted conditional logistic regression models.RESULTS: After correction for multiple testing, subjects with higher concentrations of RBC stearic acid were at higher risk for CRC (OR=1.23; 95% CI=1.07-1.42, per 1 mol%). Conversely, CRC incidence decreased with increasing proportions of RBC n-3 PUFA, particularly eicosapentaenoic acid (0.75; 0.62-0.92, per 1 mol%). The findings for the n-6 PUFA arachidonic acid were inconsistent.CONCLUSIONS: The positive association between pre-diagnostic RBC stearic acid and CRC reflects putative differences in FA intake and metabolism between cancer cases and matched controls which deserve further investigation. The inverse relationship between EPA and CRC is in line with the repeatedly reported protective effect of fish consumption on CRC risk.IMPACT: These findings add to the evidence on CRC prevention.",

author = "Jakob Linseisen and Nina Grundmann and Dorothee Zoller and Tilman Kuehn and Jansen, {Eugene H J M} and Veronique Chajes and Veronika Fedirko and Elisabete Weiderpass and Dahm, {Christina C} and Kim Overvad and Anne Tjonneland and Marie-Christine Boutron-Ruault and Rothwell, {Joseph A} and Gianluca Severi and Rudolf Kaaks and Schulze, {Matthias B} and Krasimira Aleksandrova and Sabina Sieri and Salvatore Panico and Rosario Tumino and Giovanna Masala and {De Marco}, Laura and Bas Bueno-de-Mesquita and Roel Vermeulen and Gram, {Inger T} and Guri Skeie and Maria-Dolores Chirlaque and Eva Ardanaz and Antonio Agudo and Maria-Jose S{\'a}nchez and Pilar Amiano and Maria Wennberg and Stina Bod{\'e}n and Aurora Perez-Cornago and Aglago, {Elom Kouassivi} and Gunter, {Marc J} and Mazda Jenab and Heath, {Alicia K} and Alexandra Nieters",

note = "Copyright {\textcopyright}2021, American Association for Cancer Research.",

year = "2021",

month = feb,

day = "22",

doi = "10.1158/1055-9965.EPI-20-1426",

language = "English",

journal = "Cancer Epidemiology Biomarkers & Prevention",

issn = "1055-9965",

publisher = "American Association for Cancer Research Inc.",

}

Linseisen, J, Grundmann, N, Zoller, D, Kuehn, T, Jansen, EHJM, Chajes, V, Fedirko, V, Weiderpass, E, Dahm, CC, Overvad, K, Tjonneland, A, Boutron-Ruault, M-C, Rothwell, JA, Severi, G, Kaaks, R, Schulze, MB, Aleksandrova, K, Sieri, S, Panico, S, Tumino, R, Masala, G, De Marco, L, Bueno-de-Mesquita, B, Vermeulen, R, Gram, IT, Skeie, G, Chirlaque, M-D, Ardanaz, E, Agudo, A, Sánchez, M-J, Amiano, P, Wennberg, M, Bodén, S, Perez-Cornago, A, Aglago, EK, Gunter, MJ, Jenab, M, Heath, AK & Nieters, A 2021, 'Red blood cell fatty acids and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)', Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. https://doi.org/10.1158/1055-9965.EPI-20-1426

Red blood cell fatty acids and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). / Linseisen, Jakob; Grundmann, Nina; Zoller, Dorothee; Kuehn, Tilman; Jansen, Eugene H J M; Chajes, Veronique; Fedirko, Veronika; Weiderpass, Elisabete; Dahm, Christina C; Overvad, Kim; Tjonneland, Anne; Boutron-Ruault, Marie-Christine; Rothwell, Joseph A; Severi, Gianluca; Kaaks, Rudolf; Schulze, Matthias B; Aleksandrova, Krasimira; Sieri, Sabina; Panico, Salvatore; Tumino, Rosario; Masala, Giovanna; De Marco, Laura; Bueno-de-Mesquita, Bas; Vermeulen, Roel; Gram, Inger T; Skeie, Guri; Chirlaque, Maria-Dolores; Ardanaz, Eva; Agudo, Antonio; Sánchez, Maria-Jose; Amiano, Pilar; Wennberg, Maria; Bodén, Stina; Perez-Cornago, Aurora; Aglago, Elom Kouassivi; Gunter, Marc J; Jenab, Mazda; Heath, Alicia K; Nieters, Alexandra.

In: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 22.02.2021.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Red blood cell fatty acids and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

AU - Linseisen, Jakob

AU - Grundmann, Nina

AU - Zoller, Dorothee

AU - Kuehn, Tilman

AU - Jansen, Eugene H J M

AU - Chajes, Veronique

AU - Fedirko, Veronika

AU - Weiderpass, Elisabete

AU - Dahm, Christina C

AU - Overvad, Kim

AU - Tjonneland, Anne

AU - Boutron-Ruault, Marie-Christine

AU - Rothwell, Joseph A

AU - Severi, Gianluca

AU - Kaaks, Rudolf

AU - Schulze, Matthias B

AU - Aleksandrova, Krasimira

AU - Sieri, Sabina

AU - Panico, Salvatore

AU - Tumino, Rosario

AU - Masala, Giovanna

AU - De Marco, Laura

AU - Bueno-de-Mesquita, Bas

AU - Vermeulen, Roel

AU - Gram, Inger T

AU - Skeie, Guri

AU - Chirlaque, Maria-Dolores

AU - Ardanaz, Eva

AU - Agudo, Antonio

AU - Sánchez, Maria-Jose

AU - Amiano, Pilar

AU - Wennberg, Maria

AU - Bodén, Stina

AU - Perez-Cornago, Aurora

AU - Aglago, Elom Kouassivi

AU - Gunter, Marc J

AU - Jenab, Mazda

AU - Heath, Alicia K

AU - Nieters, Alexandra

PY - 2021/2/22

Y1 - 2021/2/22

N2 - BACKGROUND: A growing body of evidence suggests that alterations of dietary fatty acid (FA) profiles are associated with colorectal cancer (CRC) risk. However, data from large-scale epidemiological studies using circulating FA measurements to objectively assess individual FA and FA categories are scarce.METHODS: To investigate the association between red blood cell (RBC) membrane FAs and risk of CRC in a case-control study nested within a large prospective cohort. After a median follow-up of 6.4 years, 1069 incident CRC cases were identified and matched to 1069 controls among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). The FA composition of RBC phospholipids (in mol%) was analyzed by gas chromatography, and their association with risk of CRC was estimated by multivariable adjusted conditional logistic regression models.RESULTS: After correction for multiple testing, subjects with higher concentrations of RBC stearic acid were at higher risk for CRC (OR=1.23; 95% CI=1.07-1.42, per 1 mol%). Conversely, CRC incidence decreased with increasing proportions of RBC n-3 PUFA, particularly eicosapentaenoic acid (0.75; 0.62-0.92, per 1 mol%). The findings for the n-6 PUFA arachidonic acid were inconsistent.CONCLUSIONS: The positive association between pre-diagnostic RBC stearic acid and CRC reflects putative differences in FA intake and metabolism between cancer cases and matched controls which deserve further investigation. The inverse relationship between EPA and CRC is in line with the repeatedly reported protective effect of fish consumption on CRC risk.IMPACT: These findings add to the evidence on CRC prevention.

AB - BACKGROUND: A growing body of evidence suggests that alterations of dietary fatty acid (FA) profiles are associated with colorectal cancer (CRC) risk. However, data from large-scale epidemiological studies using circulating FA measurements to objectively assess individual FA and FA categories are scarce.METHODS: To investigate the association between red blood cell (RBC) membrane FAs and risk of CRC in a case-control study nested within a large prospective cohort. After a median follow-up of 6.4 years, 1069 incident CRC cases were identified and matched to 1069 controls among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). The FA composition of RBC phospholipids (in mol%) was analyzed by gas chromatography, and their association with risk of CRC was estimated by multivariable adjusted conditional logistic regression models.RESULTS: After correction for multiple testing, subjects with higher concentrations of RBC stearic acid were at higher risk for CRC (OR=1.23; 95% CI=1.07-1.42, per 1 mol%). Conversely, CRC incidence decreased with increasing proportions of RBC n-3 PUFA, particularly eicosapentaenoic acid (0.75; 0.62-0.92, per 1 mol%). The findings for the n-6 PUFA arachidonic acid were inconsistent.CONCLUSIONS: The positive association between pre-diagnostic RBC stearic acid and CRC reflects putative differences in FA intake and metabolism between cancer cases and matched controls which deserve further investigation. The inverse relationship between EPA and CRC is in line with the repeatedly reported protective effect of fish consumption on CRC risk.IMPACT: These findings add to the evidence on CRC prevention.

U2 - 10.1158/1055-9965.EPI-20-1426

DO - 10.1158/1055-9965.EPI-20-1426

M3 - Article

C2 - 33619024

JO - Cancer Epidemiology Biomarkers & Prevention

JF - Cancer Epidemiology Biomarkers & Prevention

SN - 1055-9965

ER -

Linseisen J, Grundmann N, Zoller D, Kuehn T, Jansen EHJM, Chajes V et al. Red blood cell fatty acids and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2021 Feb 22. https://doi.org/10.1158/1055-9965.EPI-20-1426

Red blood cell fatty acids and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this