Reduced risk of pancreatic cancer associated with asthma and nasal allergies

Paulina Gomez-Rubio, Jan-Paul Zock, Marta Rava, Mirari Marquez, Linda Sharp, Manuel Hidalgo, Alfredo Carrato, Lucas Ilzarbe, Christoph Michalski, Xavier Molero, Antoni Farré, José Perea, William Greenhalf, Michael O'Rorke, Adonina Tardón, Thomas Gress, Victor Barberà, Tatjana Crnogorac-Jurcevic, Enrique Domínguez-Muñoz, Luís Muñoz-BellvísCristina Alvarez-Urturi, Joaquim Balcells, Luis Barneo, Eithne Costello, Carmen Guillén-Ponce, Jörg Kleeff, Bo Kong, Rita Lawlor, Matthias Löhr, Josefina Mora, Liam Murray, Damian O'Driscoll, Pablo Peláez, Ignasi Poves, Aldo Scarpa, Francisco X Real, Núria Malats, PanGenEU Study Investigators

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

OBJECTIVE: Studies indicate an inverse association between ductal adenocarcinoma of the pancreas (PDAC) and nasal allergies. However, controversial findings are reported for the association with asthma. Understanding PDAC risk factors will help us to implement appropriate strategies to prevent, treat and diagnose this cancer. This study assessed and characterised the association between PDAC and asthma and corroborated existing reports regarding the association between allergies and PDAC risk.

DESIGN: Information about asthma and allergies was collated from 1297 PDAC cases and 1024 controls included in the PanGenEU case-control study. Associations between PDAC and atopic diseases were studied using multilevel logistic regression analysis. Meta-analyses of association studies on these diseases and PDAC risk were performed applying random-effects model.

RESULTS: Asthma was associated with lower risk of PDAC (OR 0.64, 95% CI 0.47 to 0.88), particularly long-standing asthma (>=17 years, OR 0.39, 95% CI 0.24 to 0.65). Meta-analysis of 10 case-control studies sustained our results (metaOR 0.73, 95% CI 0.59 to 0.89). Nasal allergies and related symptoms were associated with lower risk of PDAC (OR 0.66, 95% CI 0.52 to 0.83 and OR 0.59, 95% CI 0.46 to 0.77, respectively). These results were supported by a meta-analysis of nasal allergy studies (metaOR 0.6, 95% CI 0.5 to 0.72). Skin allergies were not associated with PDAC risk.

CONCLUSIONS: This study shows a consistent inverse association between PDAC and asthma and nasal allergies, supporting the notion that atopic diseases are associated with reduced cancer risk. These results point to the involvement of immune and/or inflammatory factors that may either foster or restrain pancreas carcinogenesis warranting further research to understand the molecular mechanisms driving this association.

Original languageEnglish
JournalGut
Early online date01 Dec 2015
DOIs
Publication statusEarly online date - 01 Dec 2015

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Pancreatic Neoplasms
Nose
Hypersensitivity
Asthma
Meta-Analysis
Case-Control Studies
Pancreas
Neoplasms
Carcinogenesis
Adenocarcinoma
Logistic Models
Regression Analysis
Skin
Research

Bibliographical note

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Cite this

Gomez-Rubio, P., Zock, J-P., Rava, M., Marquez, M., Sharp, L., Hidalgo, M., ... PanGenEU Study Investigators (2015). Reduced risk of pancreatic cancer associated with asthma and nasal allergies. Gut. https://doi.org/10.1136/gutjnl-2015-310442
Gomez-Rubio, Paulina ; Zock, Jan-Paul ; Rava, Marta ; Marquez, Mirari ; Sharp, Linda ; Hidalgo, Manuel ; Carrato, Alfredo ; Ilzarbe, Lucas ; Michalski, Christoph ; Molero, Xavier ; Farré, Antoni ; Perea, José ; Greenhalf, William ; O'Rorke, Michael ; Tardón, Adonina ; Gress, Thomas ; Barberà, Victor ; Crnogorac-Jurcevic, Tatjana ; Domínguez-Muñoz, Enrique ; Muñoz-Bellvís, Luís ; Alvarez-Urturi, Cristina ; Balcells, Joaquim ; Barneo, Luis ; Costello, Eithne ; Guillén-Ponce, Carmen ; Kleeff, Jörg ; Kong, Bo ; Lawlor, Rita ; Löhr, Matthias ; Mora, Josefina ; Murray, Liam ; O'Driscoll, Damian ; Peláez, Pablo ; Poves, Ignasi ; Scarpa, Aldo ; Real, Francisco X ; Malats, Núria ; PanGenEU Study Investigators. / Reduced risk of pancreatic cancer associated with asthma and nasal allergies. In: Gut. 2015.
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title = "Reduced risk of pancreatic cancer associated with asthma and nasal allergies",
abstract = "OBJECTIVE: Studies indicate an inverse association between ductal adenocarcinoma of the pancreas (PDAC) and nasal allergies. However, controversial findings are reported for the association with asthma. Understanding PDAC risk factors will help us to implement appropriate strategies to prevent, treat and diagnose this cancer. This study assessed and characterised the association between PDAC and asthma and corroborated existing reports regarding the association between allergies and PDAC risk.DESIGN: Information about asthma and allergies was collated from 1297 PDAC cases and 1024 controls included in the PanGenEU case-control study. Associations between PDAC and atopic diseases were studied using multilevel logistic regression analysis. Meta-analyses of association studies on these diseases and PDAC risk were performed applying random-effects model.RESULTS: Asthma was associated with lower risk of PDAC (OR 0.64, 95{\%} CI 0.47 to 0.88), particularly long-standing asthma (>=17 years, OR 0.39, 95{\%} CI 0.24 to 0.65). Meta-analysis of 10 case-control studies sustained our results (metaOR 0.73, 95{\%} CI 0.59 to 0.89). Nasal allergies and related symptoms were associated with lower risk of PDAC (OR 0.66, 95{\%} CI 0.52 to 0.83 and OR 0.59, 95{\%} CI 0.46 to 0.77, respectively). These results were supported by a meta-analysis of nasal allergy studies (metaOR 0.6, 95{\%} CI 0.5 to 0.72). Skin allergies were not associated with PDAC risk.CONCLUSIONS: This study shows a consistent inverse association between PDAC and asthma and nasal allergies, supporting the notion that atopic diseases are associated with reduced cancer risk. These results point to the involvement of immune and/or inflammatory factors that may either foster or restrain pancreas carcinogenesis warranting further research to understand the molecular mechanisms driving this association.",
author = "Paulina Gomez-Rubio and Jan-Paul Zock and Marta Rava and Mirari Marquez and Linda Sharp and Manuel Hidalgo and Alfredo Carrato and Lucas Ilzarbe and Christoph Michalski and Xavier Molero and Antoni Farr{\'e} and Jos{\'e} Perea and William Greenhalf and Michael O'Rorke and Adonina Tard{\'o}n and Thomas Gress and Victor Barber{\`a} and Tatjana Crnogorac-Jurcevic and Enrique Dom{\'i}nguez-Mu{\~n}oz and Lu{\'i}s Mu{\~n}oz-Bellv{\'i}s and Cristina Alvarez-Urturi and Joaquim Balcells and Luis Barneo and Eithne Costello and Carmen Guill{\'e}n-Ponce and J{\"o}rg Kleeff and Bo Kong and Rita Lawlor and Matthias L{\"o}hr and Josefina Mora and Liam Murray and Damian O'Driscoll and Pablo Pel{\'a}ez and Ignasi Poves and Aldo Scarpa and Real, {Francisco X} and N{\'u}ria Malats and {PanGenEU Study Investigators}",
note = "Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/",
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Gomez-Rubio, P, Zock, J-P, Rava, M, Marquez, M, Sharp, L, Hidalgo, M, Carrato, A, Ilzarbe, L, Michalski, C, Molero, X, Farré, A, Perea, J, Greenhalf, W, O'Rorke, M, Tardón, A, Gress, T, Barberà, V, Crnogorac-Jurcevic, T, Domínguez-Muñoz, E, Muñoz-Bellvís, L, Alvarez-Urturi, C, Balcells, J, Barneo, L, Costello, E, Guillén-Ponce, C, Kleeff, J, Kong, B, Lawlor, R, Löhr, M, Mora, J, Murray, L, O'Driscoll, D, Peláez, P, Poves, I, Scarpa, A, Real, FX, Malats, N & PanGenEU Study Investigators 2015, 'Reduced risk of pancreatic cancer associated with asthma and nasal allergies', Gut. https://doi.org/10.1136/gutjnl-2015-310442

Reduced risk of pancreatic cancer associated with asthma and nasal allergies. / Gomez-Rubio, Paulina; Zock, Jan-Paul; Rava, Marta; Marquez, Mirari; Sharp, Linda; Hidalgo, Manuel; Carrato, Alfredo; Ilzarbe, Lucas; Michalski, Christoph; Molero, Xavier; Farré, Antoni; Perea, José; Greenhalf, William; O'Rorke, Michael; Tardón, Adonina; Gress, Thomas; Barberà, Victor; Crnogorac-Jurcevic, Tatjana; Domínguez-Muñoz, Enrique; Muñoz-Bellvís, Luís; Alvarez-Urturi, Cristina; Balcells, Joaquim; Barneo, Luis; Costello, Eithne; Guillén-Ponce, Carmen; Kleeff, Jörg; Kong, Bo; Lawlor, Rita; Löhr, Matthias; Mora, Josefina; Murray, Liam; O'Driscoll, Damian; Peláez, Pablo; Poves, Ignasi; Scarpa, Aldo; Real, Francisco X; Malats, Núria; PanGenEU Study Investigators.

In: Gut, 01.12.2015.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Reduced risk of pancreatic cancer associated with asthma and nasal allergies

AU - Gomez-Rubio, Paulina

AU - Zock, Jan-Paul

AU - Rava, Marta

AU - Marquez, Mirari

AU - Sharp, Linda

AU - Hidalgo, Manuel

AU - Carrato, Alfredo

AU - Ilzarbe, Lucas

AU - Michalski, Christoph

AU - Molero, Xavier

AU - Farré, Antoni

AU - Perea, José

AU - Greenhalf, William

AU - O'Rorke, Michael

AU - Tardón, Adonina

AU - Gress, Thomas

AU - Barberà, Victor

AU - Crnogorac-Jurcevic, Tatjana

AU - Domínguez-Muñoz, Enrique

AU - Muñoz-Bellvís, Luís

AU - Alvarez-Urturi, Cristina

AU - Balcells, Joaquim

AU - Barneo, Luis

AU - Costello, Eithne

AU - Guillén-Ponce, Carmen

AU - Kleeff, Jörg

AU - Kong, Bo

AU - Lawlor, Rita

AU - Löhr, Matthias

AU - Mora, Josefina

AU - Murray, Liam

AU - O'Driscoll, Damian

AU - Peláez, Pablo

AU - Poves, Ignasi

AU - Scarpa, Aldo

AU - Real, Francisco X

AU - Malats, Núria

AU - PanGenEU Study Investigators

N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

PY - 2015/12/1

Y1 - 2015/12/1

N2 - OBJECTIVE: Studies indicate an inverse association between ductal adenocarcinoma of the pancreas (PDAC) and nasal allergies. However, controversial findings are reported for the association with asthma. Understanding PDAC risk factors will help us to implement appropriate strategies to prevent, treat and diagnose this cancer. This study assessed and characterised the association between PDAC and asthma and corroborated existing reports regarding the association between allergies and PDAC risk.DESIGN: Information about asthma and allergies was collated from 1297 PDAC cases and 1024 controls included in the PanGenEU case-control study. Associations between PDAC and atopic diseases were studied using multilevel logistic regression analysis. Meta-analyses of association studies on these diseases and PDAC risk were performed applying random-effects model.RESULTS: Asthma was associated with lower risk of PDAC (OR 0.64, 95% CI 0.47 to 0.88), particularly long-standing asthma (>=17 years, OR 0.39, 95% CI 0.24 to 0.65). Meta-analysis of 10 case-control studies sustained our results (metaOR 0.73, 95% CI 0.59 to 0.89). Nasal allergies and related symptoms were associated with lower risk of PDAC (OR 0.66, 95% CI 0.52 to 0.83 and OR 0.59, 95% CI 0.46 to 0.77, respectively). These results were supported by a meta-analysis of nasal allergy studies (metaOR 0.6, 95% CI 0.5 to 0.72). Skin allergies were not associated with PDAC risk.CONCLUSIONS: This study shows a consistent inverse association between PDAC and asthma and nasal allergies, supporting the notion that atopic diseases are associated with reduced cancer risk. These results point to the involvement of immune and/or inflammatory factors that may either foster or restrain pancreas carcinogenesis warranting further research to understand the molecular mechanisms driving this association.

AB - OBJECTIVE: Studies indicate an inverse association between ductal adenocarcinoma of the pancreas (PDAC) and nasal allergies. However, controversial findings are reported for the association with asthma. Understanding PDAC risk factors will help us to implement appropriate strategies to prevent, treat and diagnose this cancer. This study assessed and characterised the association between PDAC and asthma and corroborated existing reports regarding the association between allergies and PDAC risk.DESIGN: Information about asthma and allergies was collated from 1297 PDAC cases and 1024 controls included in the PanGenEU case-control study. Associations between PDAC and atopic diseases were studied using multilevel logistic regression analysis. Meta-analyses of association studies on these diseases and PDAC risk were performed applying random-effects model.RESULTS: Asthma was associated with lower risk of PDAC (OR 0.64, 95% CI 0.47 to 0.88), particularly long-standing asthma (>=17 years, OR 0.39, 95% CI 0.24 to 0.65). Meta-analysis of 10 case-control studies sustained our results (metaOR 0.73, 95% CI 0.59 to 0.89). Nasal allergies and related symptoms were associated with lower risk of PDAC (OR 0.66, 95% CI 0.52 to 0.83 and OR 0.59, 95% CI 0.46 to 0.77, respectively). These results were supported by a meta-analysis of nasal allergy studies (metaOR 0.6, 95% CI 0.5 to 0.72). Skin allergies were not associated with PDAC risk.CONCLUSIONS: This study shows a consistent inverse association between PDAC and asthma and nasal allergies, supporting the notion that atopic diseases are associated with reduced cancer risk. These results point to the involvement of immune and/or inflammatory factors that may either foster or restrain pancreas carcinogenesis warranting further research to understand the molecular mechanisms driving this association.

U2 - 10.1136/gutjnl-2015-310442

DO - 10.1136/gutjnl-2015-310442

M3 - Article

C2 - 26628509

JO - Gut

JF - Gut

SN - 0017-5749

ER -

Gomez-Rubio P, Zock J-P, Rava M, Marquez M, Sharp L, Hidalgo M et al. Reduced risk of pancreatic cancer associated with asthma and nasal allergies. Gut. 2015 Dec 1. https://doi.org/10.1136/gutjnl-2015-310442