Regenerated cellulose matrix-encapsulated active substances and method therefor.

John David Holbrey (Inventor), Scott K. Spear (Inventor), Megan B. Turner (Inventor), Richard Patrick Swatloski (Inventor), Robin Don. Rogers (Inventor)

Research output: Patent


The process involves encapsulation or immobilization of the active solid substance in a cellulose framework by regenerating cellulose dissolved in an ionic liq. solvent in a regenerating soln. The active substance can be initially present in the ionic liq. or in the regenerating solvent either as a soln. or dispersion. The invention is applicable to mol. encapsulation and to entrapping of larger particles including enzymes, nanoparticles and macroscopic components, and to the formation of bulk materials with a wide range of morphol. forms. Thus, carbamoylmethylphosphine oxide (I) encapsulated in a cellulose matrix was realized by adding I to a 10% soln. of cellulose in 1-butyl-3-methylimidazolium chloride (ionic liq.) under vigorous stirring and then removing the ionic liq. with water. [on SciFinder(R)]
Original languageEnglish
Patent numberUS20040038031A1
Publication statusPublished - 26 Feb 2004

Bibliographical note

CAPLUS AN 2004:162249(Patent)


  • ionic liq regenerated cellulose encapsulation active substance
  • carbamoylmethylphosphine oxide encapsulation regenerated cellulose


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