Regulation of Gene Expression: Basic Mechanisms

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The study of genes and the mechanism whereby the information they hold is converted into proteins and enzymes, hormones, and intracellular signaling molecules is the realm of molecular biology. Except for the erythrocyte, all cells in the body have the same DNA complement. One of the most fascinating aspects of this work is the study of the mechanisms that control differential gene expression, both in time and in place, and the consequences if these control mechanisms are disrupted.
The goal of this chapter is to introduce the basic concepts involved in regulation of protein-coding genes and how these processes are involved in the causation of human disease. The basic mechanism of gene regulation will be described first, followed by a discussion of a specific gene regulation system to highlight various aspects of the basic mechanism. The chapter will end with a discussion of various ways in which the gene regulatory apparatus can be adapted to suit the needs of different tissues and situations.
Original languageEnglish
Title of host publicationMedical Biochemistry
EditorsJohn Baynes, Marek Dominiczak
Place of PublicationUSA
PublisherElsevier
Chapter23
Number of pages12
Edition5
ISBN (Electronic)9780702078231
ISBN (Print)9780702072994
Publication statusPublished - 27 Feb 2018

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    Hyland, E. M. (2018). Regulation of Gene Expression: Basic Mechanisms. In J. Baynes, & M. Dominiczak (Eds.), Medical Biochemistry (5 ed.). Elsevier.