Regulation of Gene Expression: Basic Mechanisms

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The study of genes and the mechanism whereby the information they hold is converted into proteins and enzymes, hormones, and intracellular signaling molecules is the realm of molecular biology. Except for the erythrocyte, all cells in the body have the same DNA complement. One of the most fascinating aspects of this work is the study of the mechanisms that control differential gene expression, both in time and in place, and the consequences if these control mechanisms are disrupted.
The goal of this chapter is to introduce the basic concepts involved in regulation of protein-coding genes and how these processes are involved in the causation of human disease. The basic mechanism of gene regulation will be described first, followed by a discussion of a specific gene regulation system to highlight various aspects of the basic mechanism. The chapter will end with a discussion of various ways in which the gene regulatory apparatus can be adapted to suit the needs of different tissues and situations.
LanguageEnglish
Title of host publicationMedical Biochemistry
EditorsJohn Baynes, Marek Dominiczak
Place of PublicationUSA
PublisherElsevier
Chapter23
Number of pages12
Edition5
ISBN (Electronic)9780702078231
ISBN (Print)9780702072994
Publication statusPublished - 27 Feb 2018

Fingerprint

Gene Expression Regulation
Genes
Regulator Genes
Causality
Molecular Biology
Proteins
Erythrocytes
Hormones
Gene Expression
DNA
Enzymes

Cite this

Hyland, E. M. (2018). Regulation of Gene Expression: Basic Mechanisms. In J. Baynes, & M. Dominiczak (Eds.), Medical Biochemistry (5 ed.). USA: Elsevier.
Hyland, Edel M. / Regulation of Gene Expression: Basic Mechanisms. Medical Biochemistry. editor / John Baynes ; Marek Dominiczak. 5. ed. USA : Elsevier, 2018.
@inbook{9a971069ecc94368aba96ee97a7c92fd,
title = "Regulation of Gene Expression: Basic Mechanisms",
abstract = "The study of genes and the mechanism whereby the information they hold is converted into proteins and enzymes, hormones, and intracellular signaling molecules is the realm of molecular biology. Except for the erythrocyte, all cells in the body have the same DNA complement. One of the most fascinating aspects of this work is the study of the mechanisms that control differential gene expression, both in time and in place, and the consequences if these control mechanisms are disrupted.The goal of this chapter is to introduce the basic concepts involved in regulation of protein-coding genes and how these processes are involved in the causation of human disease. The basic mechanism of gene regulation will be described first, followed by a discussion of a specific gene regulation system to highlight various aspects of the basic mechanism. The chapter will end with a discussion of various ways in which the gene regulatory apparatus can be adapted to suit the needs of different tissues and situations.",
author = "Hyland, {Edel M.}",
year = "2018",
month = "2",
day = "27",
language = "English",
isbn = "9780702072994",
editor = "John Baynes and Marek Dominiczak",
booktitle = "Medical Biochemistry",
publisher = "Elsevier",
address = "United States",
edition = "5",

}

Hyland, EM 2018, Regulation of Gene Expression: Basic Mechanisms. in J Baynes & M Dominiczak (eds), Medical Biochemistry. 5 edn, Elsevier, USA.

Regulation of Gene Expression: Basic Mechanisms. / Hyland, Edel M.

Medical Biochemistry. ed. / John Baynes; Marek Dominiczak. 5. ed. USA : Elsevier, 2018.

Research output: Chapter in Book/Report/Conference proceedingChapter

TY - CHAP

T1 - Regulation of Gene Expression: Basic Mechanisms

AU - Hyland, Edel M.

PY - 2018/2/27

Y1 - 2018/2/27

N2 - The study of genes and the mechanism whereby the information they hold is converted into proteins and enzymes, hormones, and intracellular signaling molecules is the realm of molecular biology. Except for the erythrocyte, all cells in the body have the same DNA complement. One of the most fascinating aspects of this work is the study of the mechanisms that control differential gene expression, both in time and in place, and the consequences if these control mechanisms are disrupted.The goal of this chapter is to introduce the basic concepts involved in regulation of protein-coding genes and how these processes are involved in the causation of human disease. The basic mechanism of gene regulation will be described first, followed by a discussion of a specific gene regulation system to highlight various aspects of the basic mechanism. The chapter will end with a discussion of various ways in which the gene regulatory apparatus can be adapted to suit the needs of different tissues and situations.

AB - The study of genes and the mechanism whereby the information they hold is converted into proteins and enzymes, hormones, and intracellular signaling molecules is the realm of molecular biology. Except for the erythrocyte, all cells in the body have the same DNA complement. One of the most fascinating aspects of this work is the study of the mechanisms that control differential gene expression, both in time and in place, and the consequences if these control mechanisms are disrupted.The goal of this chapter is to introduce the basic concepts involved in regulation of protein-coding genes and how these processes are involved in the causation of human disease. The basic mechanism of gene regulation will be described first, followed by a discussion of a specific gene regulation system to highlight various aspects of the basic mechanism. The chapter will end with a discussion of various ways in which the gene regulatory apparatus can be adapted to suit the needs of different tissues and situations.

M3 - Chapter

SN - 9780702072994

BT - Medical Biochemistry

A2 - Baynes, John

A2 - Dominiczak, Marek

PB - Elsevier

CY - USA

ER -

Hyland EM. Regulation of Gene Expression: Basic Mechanisms. In Baynes J, Dominiczak M, editors, Medical Biochemistry. 5 ed. USA: Elsevier. 2018