Rehabilitation outcomes for people with lung cancer (UNITE): protocol for the development of a core outcome set

Lara Edbrooke, Catherine L Granger, Jill J Francis, Tom John, Nasreen Kaadan, Emma Halloran, Bronwen Connolly, Linda Denehy

Research output: Contribution to journalArticlepeer-review

4 Downloads (Pure)


Introduction: With treatment-related improvements in survival, rehabilitation is essential to improve function and health-related quality of life and manage the high symptom burden associated with lung cancer. Despite this, significant heterogeneity exists in the outcomes and instruments used to evaluate lung cancer rehabilitation programme impact. This study aims to develop a core set of clinically relevant lung cancer rehabilitation outcomes for use in clinical practice.

Methods and analysis: An international Delphi consensus study involving consumer, healthcare professional and researcher stakeholders to determine which outcomes to include and how to measure these. Stage 1 (preliminary): mixed methods to develop the potential list of outcomes (1) overview of systematic reviews of lung cancer exercise interventions and (2) focus groups and individual interviews with people with lung cancer. Stage 2: outcomes were grouped according to the International Classification of Functioning, Disability and Health domains. Stage 3: to determine priority outcomes for core outcome set (COS) inclusion participants will rate each outcome’s importance (one-nine-point Likert scale) over two-three survey rounds. Stage 4: following review by the steering committee, a consensus meeting will be held if agreement on the COS has not been reached.

Stage 5: recommendations will be made regarding a single instrument for measuring each COS outcome by reviewing existing resources where consensus has already been reached. Where resources do not exist the quality and feasibility of potential measurement instruments will be appraised, and the Delphi consensus survey and meeting process outlined in stages 3–4 will be repeated.
Original languageEnglish
Article numbere001571
JournalBMJ Open Respiratory Research
Issue number1
Publication statusPublished - 19 Jun 2023


  • Quality of Life
  • Lung Neoplasms
  • Pulmonary Rehabilitation
  • Delphi Technique
  • Treatment Outcome
  • Humans
  • Exercise
  • Lung Cancer
  • Research Design
  • Systematic Reviews as Topic


Dive into the research topics of 'Rehabilitation outcomes for people with lung cancer (UNITE): protocol for the development of a core outcome set'. Together they form a unique fingerprint.

Cite this