Relation of birth weight, body mass index, and change in size from birth to adulthood to insulin resistance in a female twin cohort

Paula M. L. Skidmore; Aedin Cassidy; Ramasamyiyer Swaminathan; J. Brent Richards; Tim D. Spector; Alex J. MacGregor

doi:10.1210/jc.2007-1424

Relation of birth weight, body mass index, and change in size from birth to adulthood to insulin resistance in a female twin cohort

Paula M. L. Skidmore, Aedin Cassidy, Ramasamyiyer Swaminathan, J. Brent Richards, Tim D. Spector, Alex J. MacGregor

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Because an adverse intrauterine environment is thought to induce insulin resistance, our objective was to investigate the relationships between birth weight, BMI, and change in body size over the life course and insulin resistance. SETTING, DESIGN, AND PARTICIPANTS: We conducted a cross-sectional study in a cohort of 1194 female twins aged 18-74 yr. The relationship between birth weight and insulin resistance was analyzed using a regression method allowing for a simultaneous estimation of within- and between-pair influences. The approach allows the influence of individual fetal nutrition on adult insulin resistance to be distinguished from effects that are mediated by confounding factors in the maternal environment.

Original language	English
Pages (from-to)	516-520
Number of pages	5
Journal	The Journal of Clinical Endocrinology & Metabolism
Volume	93
Issue number	2
DOIs	https://doi.org/10.1210/jc.2007-1424
Publication status	Published - 01 Feb 2008

Keywords

Adolescent
Adult
Aged
Birth Weight
Blood Glucose
Body Mass Index
Cohort Studies
Cross-Sectional Studies
Female
Humans
Infant
Newborn
Insulin
Insulin Resistance
Linear Models
Middle Aged
Twins
Dizygotic
Monozygotic

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10.1210/jc.2007-1424

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title = "Relation of birth weight, body mass index, and change in size from birth to adulthood to insulin resistance in a female twin cohort",

abstract = "Because an adverse intrauterine environment is thought to induce insulin resistance, our objective was to investigate the relationships between birth weight, BMI, and change in body size over the life course and insulin resistance. SETTING, DESIGN, AND PARTICIPANTS: We conducted a cross-sectional study in a cohort of 1194 female twins aged 18-74 yr. The relationship between birth weight and insulin resistance was analyzed using a regression method allowing for a simultaneous estimation of within- and between-pair influences. The approach allows the influence of individual fetal nutrition on adult insulin resistance to be distinguished from effects that are mediated by confounding factors in the maternal environment.",

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author = "Skidmore, {Paula M. L.} and Aedin Cassidy and Ramasamyiyer Swaminathan and Richards, {J. Brent} and Spector, {Tim D.} and MacGregor, {Alex J.}",

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doi = "10.1210/jc.2007-1424",

language = "English",

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journal = "The Journal of Clinical Endocrinology & Metabolism",

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Relation of birth weight, body mass index, and change in size from birth to adulthood to insulin resistance in a female twin cohort. / Skidmore, Paula M. L.; Cassidy, Aedin; Swaminathan, Ramasamyiyer et al.
In: The Journal of Clinical Endocrinology & Metabolism, Vol. 93, No. 2, 01.02.2008, p. 516-520.

Research output: Contribution to journal › Article › peer-review

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AU - Skidmore, Paula M. L.

AU - Cassidy, Aedin

AU - Swaminathan, Ramasamyiyer

AU - Richards, J. Brent

AU - Spector, Tim D.

AU - MacGregor, Alex J.

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KW - Humans

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KW - Newborn

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KW - Linear Models

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KW - Monozygotic

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JO - The Journal of Clinical Endocrinology & Metabolism

JF - The Journal of Clinical Endocrinology & Metabolism

IS - 2

ER -

Relation of birth weight, body mass index, and change in size from birth to adulthood to insulin resistance in a female twin cohort

Abstract

Keywords

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