Relationship between a high-risk haplotype in the DTNBP1 (dysbindin) gene and clinical features of schizophrenia

Ayman H Fanous, Edwin J van den Oord, Brien P Riley, Steven H Aggen, Michael C Neale, F Anthony O'Neill, Dermot Walsh, Kenneth S Kendler

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128 Citations (Scopus)

Abstract

The purpose of this study was to determine whether a haplotype in the dystrobrevin binding protein 1 (DTNBP1) gene previously associated with schizophrenia not only increases the susceptibility to psychotic illness but also to a more or less clinically specific form of psychotic illness.
Original languageEnglish
Pages (from-to)1824-32
Number of pages9
JournalAmerican Journal of Psychiatry
Volume162
Issue number10
DOIs
Publication statusPublished - Oct 2005

Keywords

  • Carrier Proteins
  • Chromosomes, Human, Pair 6
  • Factor Analysis, Statistical
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genetic Variation
  • Genotype
  • Haplotypes
  • Humans
  • Ireland
  • Polymorphism, Single Nucleotide
  • Psychiatric Status Rating Scales
  • Risk Factors
  • Schizophrenia
  • Schizophrenic Psychology

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    Fanous, A. H., van den Oord, E. J., Riley, B. P., Aggen, S. H., Neale, M. C., O'Neill, F. A., Walsh, D., & Kendler, K. S. (2005). Relationship between a high-risk haplotype in the DTNBP1 (dysbindin) gene and clinical features of schizophrenia. American Journal of Psychiatry, 162(10), 1824-32. https://doi.org/10.1176/appi.ajp.162.10.1824