TY - JOUR
T1 - Relationship between oral health and glaucoma traits in the United Kingdom
AU - Lee, Rachel H.
AU - Kang, Jae H.
AU - Wiggs, Janey L.
AU - Wagner, Siegfried K.
AU - Khawaja, Anthony
AU - Pasquale, Louis R.
AU - Allen, Naomi
AU - Aslam, Tariq
AU - Atan, Denize
AU - Balaskas, Konstantinos
AU - Barman, Sarah
AU - Barrett, Jenny
AU - Bishop, Paul
AU - Black, Graeme
AU - Braithwaite, Tasanee
AU - Carare, Roxana
AU - Chakravarthy, Usha
AU - Chan, Michelle
AU - Chua, Sharon
AU - Day, Alexander
AU - Desai, Parul
AU - Dhillon, Bal
AU - Dick, Andrew
AU - Doney, Alexander
AU - Egan, Cathy
AU - Ennis, Sarah
AU - Foster, Paul
AU - Fruttiger, Marcus
AU - Gallacher, John
AU - Garway-Heath, David
AU - Gibson, Jane
AU - Guggenheim, Jeremy
AU - Hammond, Chris
AU - Hardcastle, Alison
AU - Harding, Simon
AU - Hogg, Ruth
AU - Hysi, Pirro
AU - Keane, Pearse
AU - Khaw, Peng
AU - Khawaja, Anthony
AU - Lascaratos, Gerassimos
AU - Littlejohns, Thomas
AU - Lotery, Andrew J.
AU - Luben, Robert
AU - Luthert, Phil
AU - McGuinness, Bernadette
AU - McKay, Gareth
AU - Paterson, Euan
AU - Peto, Tunde
AU - Woodside, Jayne
AU - Modifiable Risk Factors for Glaucoma Collaboration
AU - UK Biobank Eye and Vision Consortium
AU - International Glaucoma Genetics Consortium
N1 - Publisher Copyright:
© 2024 Lippincott Williams and Wilkins. All rights reserved.
PY - 2024/6/1
Y1 - 2024/6/1
N2 - Précis: In this cross-sectional analysis of UK Biobank participants, we find no adverse association between self-reported oral health conditions and either glaucoma or elevated intraocular pressures. Purpose: Poor oral health may cause inflammation, which accelerates the progression of neurodegenerative diseases. We investigated the relationship between oral health and glaucoma. Patients: United Kingdom Biobank participants. Methods: This is a cross-sectional analysis of participants categorized by self-reported oral health status. Multivariable linear and logistic regression models were used. Primary analysis examined the association with glaucoma prevalence. Secondary analyses examined associations with IOP, macular retinal nerve fiber layer (mRNFL), and ganglion cell inner plexiform layer (mGCIPL) thicknesses, and interaction terms with multitrait glaucoma polygenic risk scores (MTAG PRS) or intraocular pressure (IOP) PRS. Results: A total of 170,815 participants (34.3%) reported current oral health problems, including painful or bleeding gums, toothache, loose teeth, and/or denture wear. A In all, 33,059, 33,004, 14,652, and 14,613 participants were available for analysis of glaucoma, IOP, mRNFL, and mGCIPL, respectively. No association between oral health and glaucoma was identified [odds ratio (OR): 1.04, 95% CI: 0.95-1.14]. IOPs were slightly lower among those with oral disease (-0.08 mm Hg, 95% CI: -0.15, -0.009); specifically, among those with loose teeth (P=0.03) and denture-wearers (P<0.0001). mRNFL measurements were lower among those with oral health conditions (-0.14 μm, 95% CI: -0.27, -0.0009), but mGCIPL measurements (P=0.96) were not significantly different. A PRS for IOP or glaucoma did not modify relations between oral health and IOP or glaucoma (P for interactions ≥ 0.17). Conclusions: Self-reported oral health was not associated with elevated IOP or an increased risk of glaucoma. Future studies should confirm the null association between clinically diagnosed oral health conditions and glaucoma.
AB - Précis: In this cross-sectional analysis of UK Biobank participants, we find no adverse association between self-reported oral health conditions and either glaucoma or elevated intraocular pressures. Purpose: Poor oral health may cause inflammation, which accelerates the progression of neurodegenerative diseases. We investigated the relationship between oral health and glaucoma. Patients: United Kingdom Biobank participants. Methods: This is a cross-sectional analysis of participants categorized by self-reported oral health status. Multivariable linear and logistic regression models were used. Primary analysis examined the association with glaucoma prevalence. Secondary analyses examined associations with IOP, macular retinal nerve fiber layer (mRNFL), and ganglion cell inner plexiform layer (mGCIPL) thicknesses, and interaction terms with multitrait glaucoma polygenic risk scores (MTAG PRS) or intraocular pressure (IOP) PRS. Results: A total of 170,815 participants (34.3%) reported current oral health problems, including painful or bleeding gums, toothache, loose teeth, and/or denture wear. A In all, 33,059, 33,004, 14,652, and 14,613 participants were available for analysis of glaucoma, IOP, mRNFL, and mGCIPL, respectively. No association between oral health and glaucoma was identified [odds ratio (OR): 1.04, 95% CI: 0.95-1.14]. IOPs were slightly lower among those with oral disease (-0.08 mm Hg, 95% CI: -0.15, -0.009); specifically, among those with loose teeth (P=0.03) and denture-wearers (P<0.0001). mRNFL measurements were lower among those with oral health conditions (-0.14 μm, 95% CI: -0.27, -0.0009), but mGCIPL measurements (P=0.96) were not significantly different. A PRS for IOP or glaucoma did not modify relations between oral health and IOP or glaucoma (P for interactions ≥ 0.17). Conclusions: Self-reported oral health was not associated with elevated IOP or an increased risk of glaucoma. Future studies should confirm the null association between clinically diagnosed oral health conditions and glaucoma.
KW - dental health
KW - glaucoma
KW - intraocular pressure
KW - oral health
U2 - 10.1097/IJG.0000000000002370
DO - 10.1097/IJG.0000000000002370
M3 - Article
C2 - 38506820
AN - SCOPUS:85195227784
SN - 1057-0829
VL - 33
SP - 400
EP - 408
JO - Journal of Glaucoma
JF - Journal of Glaucoma
IS - 6
ER -