Relative activity of triclabendazole metabolites against the liver fluke, Fasciola hepatica

Liam Halferty, Gerard Brennan, Alan Trudgett, Elizabeth Hoey, Ian Fairweather

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)

Abstract

A study has been carried Out to determine the relative activity Of triclabendazole (TCBZ) and its sulphoxide (TCBZ(center dot)SO) and sulphone (TCBZ(center dot)SO(2)) metabolites against the adult stage of the liver fluke, Fasciola hepatica. Flukes were incubated for 24 h in vitro in 15 mu g/ml of each of the compounds and prepared for scanning and transmission electron microscopy.
Original languageEnglish
Pages (from-to)126-138
Number of pages13
JournalVeterinary Parasitology
Volume159
Issue number2
DOIs
Publication statusPublished - 05 Feb 2009

ASJC Scopus subject areas

  • Parasitology
  • veterinary(all)

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