Relative activity of triclabendazole metabolites against the liver fluke, Fasciola hepatica

Liam Halferty; Gerard Brennan; Alan Trudgett; Elizabeth Hoey; Ian Fairweather

doi:10.1016/j.vetpar.2008.10.007

Relative activity of triclabendazole metabolites against the liver fluke, Fasciola hepatica

Liam Halferty, Gerard Brennan, Alan Trudgett, Elizabeth Hoey, Ian Fairweather

Research output: Contribution to journal › Article › peer-review

57 Citations (Scopus)

Abstract

A study has been carried Out to determine the relative activity Of triclabendazole (TCBZ) and its sulphoxide (TCBZ(center dot)SO) and sulphone (TCBZ(center dot)SO(2)) metabolites against the adult stage of the liver fluke, Fasciola hepatica. Flukes were incubated for 24 h in vitro in 15 mu g/ml of each of the compounds and prepared for scanning and transmission electron microscopy.

Original language	English
Pages (from-to)	126-138
Number of pages	13
Journal	Veterinary Parasitology
Volume	159
Issue number	2
DOIs	https://doi.org/10.1016/j.vetpar.2008.10.007
Publication status	Published - 05 Feb 2009

ASJC Scopus subject areas

Parasitology
General Veterinary

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10.1016/j.vetpar.2008.10.007

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abstract = "A study has been carried Out to determine the relative activity Of triclabendazole (TCBZ) and its sulphoxide (TCBZ(center dot)SO) and sulphone (TCBZ(center dot)SO(2)) metabolites against the adult stage of the liver fluke, Fasciola hepatica. Flukes were incubated for 24 h in vitro in 15 mu g/ml of each of the compounds and prepared for scanning and transmission electron microscopy.",

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AB - A study has been carried Out to determine the relative activity Of triclabendazole (TCBZ) and its sulphoxide (TCBZ(center dot)SO) and sulphone (TCBZ(center dot)SO(2)) metabolites against the adult stage of the liver fluke, Fasciola hepatica. Flukes were incubated for 24 h in vitro in 15 mu g/ml of each of the compounds and prepared for scanning and transmission electron microscopy.

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Relative activity of triclabendazole metabolites against the liver fluke, Fasciola hepatica

Abstract

ASJC Scopus subject areas

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