Relative biological effectiveness (RBE) and out-of-field cell survival responses to passive scattering and pencil beam scanning proton beam deliveries

Karl T. Butterworth*, Conor K. McGarry, Ben Clasie, Alejandro Carabe-Fernandez, Jan Schuemann, Nicolas Depauw, Shikui Tang, Stephen J. McMahon, Giuseppe Schettino, Joe M. O'Sullivan, Hsaio-Ming Lu, Hanne Kooy, Harald Paganetti, Alan R. Hounsell, Kathryn D. Held, Kevin M. Prise

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

The relative biological effectiveness (RBE) of passive scattered (PS) and pencil beam scanned (PBS) proton beam delivery techniques for uniform beam configurations was determined by clonogenic survival. The radiobiological impact of modulated beam configurations on cell survival occurring in- or out-of-field for both delivery techniques was determined with intercellular communication intact or physically inhibited. Cell survival responses were compared to those observed using a 6 MV photon beam produced with a linear accelerator. DU-145 cells showed no significant difference in survival response to proton beams delivered by PS and PBS or 6 MV photons taking into account a RBE of 1.1 for protons at the centre of the spread out Bragg peak. Significant out-of-field effects similar to those observed for 6 MV photons were observed for both PS and PBS proton deliveries with cell survival decreasing to 50-60% survival for scattered doses of 0.05 and 0.03 Gy for passive scattered and pencil beam scanned beams respectively. The observed out-of-field responses were shown to be dependent on intercellular communication between the in-and out-of-field cell populations. These data demonstrate, for the first time, a similar RBE between passive and actively scanned proton beams and confirm that out-of-field effects may be important determinants of cell survival following exposure to modulated photon and proton fields

Original languageEnglish
Article number6671
Pages (from-to)6671-6680
Number of pages10
JournalPhysics in Medicine and Biology
Volume57
Issue number20
DOIs
Publication statusPublished - 21 Oct 2012

Keywords

  • MODULATED RADIATION-FIELDS
  • THERAPY
  • CANCER
  • RADIOTHERAPY
  • EXPOSURE
  • IMRT

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