Relative Biological Effectiveness Variation Along Monoenergetic and Modulated Bragg Peaks of a 62-MeV Therapeutic Proton Beam: A Preclinical Assessment

Pankaj Chaudhary, Thomas I Marshall, Francesca M Perozziello, Lorenzo Manti, Frederick J Currell, Fiona Hanton, Stephen J McMahon, Joy N Kavanagh, Giuseppe Antonio Pablo Cirrone, Francesco Romano, Kevin M Prise, Giuseppe Schettino

Research output: Contribution to journalArticlepeer-review

123 Citations (Scopus)
421 Downloads (Pure)

Abstract

iological optimization of proton therapy critically depends on detailed evaluation of relative biological effectiveness (RBE) variations along the Bragg curve. The clinically accepted RBE value of 1.1 is an oversimplification, which disregards the steep rise of linear energy transfer (LET) at the distal end of the spread-out Bragg peak. We observed significant cell killing RBE variations dependent on beam modulation, intrinsic radiosensitivity, and LET in agreement with the LEM predicted values, indicating dose-averaged LET as a suitable parameter for biological effectiveness. Data have also been used to validate a RBE parameterized model.
Original languageEnglish
Pages (from-to)27-35
Number of pages9
JournalInternational Journal of Radiation: Oncology - Biology - Physics
Volume90
Issue number1
Early online date28 Jun 2014
DOIs
Publication statusPublished - 01 Sep 2014

Fingerprint

Dive into the research topics of 'Relative Biological Effectiveness Variation Along Monoenergetic and Modulated Bragg Peaks of a 62-MeV Therapeutic Proton Beam: A Preclinical Assessment'. Together they form a unique fingerprint.

Cite this