Relative Biological Effectiveness Variation Along Monoenergetic and Modulated Bragg Peaks of a 62-MeV Therapeutic Proton Beam: A Preclinical Assessment

Pankaj Chaudhary; Thomas I Marshall; Francesca M Perozziello; Lorenzo Manti; Frederick J Currell; Fiona Hanton; Stephen J McMahon; Joy N Kavanagh; Giuseppe Antonio Pablo Cirrone; Francesco Romano; Kevin M Prise; Giuseppe Schettino

doi:10.1016/j.ijrobp.2014.05.010

Relative Biological Effectiveness Variation Along Monoenergetic and Modulated Bragg Peaks of a 62-MeV Therapeutic Proton Beam: A Preclinical Assessment

Pankaj Chaudhary, Thomas I Marshall, Francesca M Perozziello, Lorenzo Manti, Frederick J Currell, Fiona Hanton, Stephen J McMahon, Joy N Kavanagh, Giuseppe Antonio Pablo Cirrone, Francesco Romano, Kevin M Prise, Giuseppe Schettino

Research output: Contribution to journal › Article › peer-review

187 Citations (Scopus)

711 Downloads (Pure)

Abstract

iological optimization of proton therapy critically depends on detailed evaluation of relative biological effectiveness (RBE) variations along the Bragg curve. The clinically accepted RBE value of 1.1 is an oversimplification, which disregards the steep rise of linear energy transfer (LET) at the distal end of the spread-out Bragg peak. We observed significant cell killing RBE variations dependent on beam modulation, intrinsic radiosensitivity, and LET in agreement with the LEM predicted values, indicating dose-averaged LET as a suitable parameter for biological effectiveness. Data have also been used to validate a RBE parameterized model.

Original language	English
Pages (from-to)	27-35
Number of pages	9
Journal	International Journal of Radiation Oncology - Biology - Physics
Volume	90
Issue number	1
Early online date	28 Jun 2014
DOIs	https://doi.org/10.1016/j.ijrobp.2014.05.010
Publication status	Published - 01 Sept 2014

Access to Document

10.1016/j.ijrobp.2014.05.010

Relative Biological Effectiveness Variation Along Monoenergetic and Modulated Bragg Peaks of a 62-MeV Therapeutic Proton Beam: A Preclinical Assessment
© 2014 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/,which permits distribution and reproduction for non-commercial purposes, provided the author and source are cited
Accepted author manuscript, 1.77 MB

Kevin Prise
- k.prisequb.acuk
- School of Medicine, Dentistry and Biomedical Sciences - Professor
- Patrick G Johnston Centre for Cancer Research
Person: Academic

Cite this

Chaudhary, P., I Marshall, T., Perozziello, F. M., Manti, L., Currell, F. J., Hanton, F., McMahon, S. J., Kavanagh, J. N., Cirrone, G. A. P., Romano, F., Prise, K. M., & Schettino, G. (2014). Relative Biological Effectiveness Variation Along Monoenergetic and Modulated Bragg Peaks of a 62-MeV Therapeutic Proton Beam: A Preclinical Assessment. International Journal of Radiation Oncology - Biology - Physics, 90(1), 27-35. https://doi.org/10.1016/j.ijrobp.2014.05.010

@article{40a07592674c450a8af2005c46b8454a,

title = "Relative Biological Effectiveness Variation Along Monoenergetic and Modulated Bragg Peaks of a 62-MeV Therapeutic Proton Beam: A Preclinical Assessment",

abstract = "iological optimization of proton therapy critically depends on detailed evaluation of relative biological effectiveness (RBE) variations along the Bragg curve. The clinically accepted RBE value of 1.1 is an oversimplification, which disregards the steep rise of linear energy transfer (LET) at the distal end of the spread-out Bragg peak. We observed significant cell killing RBE variations dependent on beam modulation, intrinsic radiosensitivity, and LET in agreement with the LEM predicted values, indicating dose-averaged LET as a suitable parameter for biological effectiveness. Data have also been used to validate a RBE parameterized model.",

author = "Pankaj Chaudhary and {I Marshall}, Thomas and Perozziello, {Francesca M} and Lorenzo Manti and Currell, {Frederick J} and Fiona Hanton and McMahon, {Stephen J} and Kavanagh, {Joy N} and Cirrone, {Giuseppe Antonio Pablo} and Francesco Romano and Prise, {Kevin M} and Giuseppe Schettino",

year = "2014",

month = sep,

day = "1",

doi = "10.1016/j.ijrobp.2014.05.010",

language = "English",

volume = "90",

pages = "27--35",

journal = "International Journal of Radiation Oncology - Biology - Physics",

issn = "0360-3016",

publisher = "Elsevier Inc.",

number = "1",

}

Chaudhary, P, I Marshall, T, Perozziello, FM, Manti, L, Currell, FJ, Hanton, F, McMahon, SJ, Kavanagh, JN, Cirrone, GAP, Romano, F, Prise, KM & Schettino, G 2014, 'Relative Biological Effectiveness Variation Along Monoenergetic and Modulated Bragg Peaks of a 62-MeV Therapeutic Proton Beam: A Preclinical Assessment', International Journal of Radiation Oncology - Biology - Physics, vol. 90, no. 1, pp. 27-35. https://doi.org/10.1016/j.ijrobp.2014.05.010

Relative Biological Effectiveness Variation Along Monoenergetic and Modulated Bragg Peaks of a 62-MeV Therapeutic Proton Beam: A Preclinical Assessment. / Chaudhary, Pankaj; I Marshall, Thomas; Perozziello, Francesca M et al.
In: International Journal of Radiation Oncology - Biology - Physics, Vol. 90, No. 1, 01.09.2014, p. 27-35.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Relative Biological Effectiveness Variation Along Monoenergetic and Modulated Bragg Peaks of a 62-MeV Therapeutic Proton Beam: A Preclinical Assessment

AU - Chaudhary, Pankaj

AU - I Marshall, Thomas

AU - Perozziello, Francesca M

AU - Manti, Lorenzo

AU - Currell, Frederick J

AU - Hanton, Fiona

AU - McMahon, Stephen J

AU - Kavanagh, Joy N

AU - Cirrone, Giuseppe Antonio Pablo

AU - Romano, Francesco

AU - Prise, Kevin M

AU - Schettino, Giuseppe

PY - 2014/9/1

Y1 - 2014/9/1

N2 - iological optimization of proton therapy critically depends on detailed evaluation of relative biological effectiveness (RBE) variations along the Bragg curve. The clinically accepted RBE value of 1.1 is an oversimplification, which disregards the steep rise of linear energy transfer (LET) at the distal end of the spread-out Bragg peak. We observed significant cell killing RBE variations dependent on beam modulation, intrinsic radiosensitivity, and LET in agreement with the LEM predicted values, indicating dose-averaged LET as a suitable parameter for biological effectiveness. Data have also been used to validate a RBE parameterized model.

AB - iological optimization of proton therapy critically depends on detailed evaluation of relative biological effectiveness (RBE) variations along the Bragg curve. The clinically accepted RBE value of 1.1 is an oversimplification, which disregards the steep rise of linear energy transfer (LET) at the distal end of the spread-out Bragg peak. We observed significant cell killing RBE variations dependent on beam modulation, intrinsic radiosensitivity, and LET in agreement with the LEM predicted values, indicating dose-averaged LET as a suitable parameter for biological effectiveness. Data have also been used to validate a RBE parameterized model.

U2 - 10.1016/j.ijrobp.2014.05.010

DO - 10.1016/j.ijrobp.2014.05.010

M3 - Article

C2 - 24986743

SN - 0360-3016

VL - 90

SP - 27

EP - 35

JO - International Journal of Radiation Oncology - Biology - Physics

JF - International Journal of Radiation Oncology - Biology - Physics

IS - 1

ER -

Chaudhary P, I Marshall T, Perozziello FM, Manti L, Currell FJ, Hanton F et al. Relative Biological Effectiveness Variation Along Monoenergetic and Modulated Bragg Peaks of a 62-MeV Therapeutic Proton Beam: A Preclinical Assessment. International Journal of Radiation Oncology - Biology - Physics. 2014 Sept 1;90(1):27-35. Epub 2014 Jun 28. doi: 10.1016/j.ijrobp.2014.05.010

Relative Biological Effectiveness Variation Along Monoenergetic and Modulated Bragg Peaks of a 62-MeV Therapeutic Proton Beam: A Preclinical Assessment

Abstract

Access to Document

Fingerprint

Profiles

Kevin Prise

Cite this