Remodelling of the Gram-negative bacterial Kdo2-lipid A and its functional implications

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)
470 Downloads (Pure)

Abstract

The lipopolysaccharide (LPS) is a characteristic molecule of the outer leaflet of the Gram-negative bacterial outer membrane, which consists of lipid A, core oligosaccharide, and O antigen. The lipid A is embedded in outer membrane and provides an efficient permeability barrier, which is particularly important to reduce the permeability of antibiotics, toxic cationic metals, and antimicrobial peptides. LPS, an important modulator of innate immune responses ranging from localized inflammation to disseminated sepsis, displays a high level of structural and functional heterogeneity, which arise due to regulated differences in the acylation of the lipid A and the incorporation of non-stoichiometric modifications in lipid A and the core oligosaccharide. This review focuses on the current mechanistic understanding of the synthesis and assembly of the lipid A molecule and its most salient non-stoichiometric modifications.
Original languageEnglish
Article numberMIC-D-21-00388R1
JournalMicrobiology (United Kingdom)
Early online date08 Apr 2022
DOIs
Publication statusEarly online date - 08 Apr 2022

Fingerprint

Dive into the research topics of 'Remodelling of the Gram-negative bacterial Kdo2-lipid A and its functional implications'. Together they form a unique fingerprint.

Cite this