Remote conformational control of a molecular switch via methylation and deprotonation

Peter C. Knipe, Ian M. Jones, Sam Thompson, Andrew D. Hamilton

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Exacting control over conformation in response to an external stimulus is the central focus of molecular switching. Here we describe the synthesis of a series of diphenylacetylene-based molecular switches, and examine their response to covalent modification and deprotonation at remote phenolic positions. A complex interplay between multiple intramolecular hydrogen bond donors and acceptors determines the global conformation. 

LanguageEnglish
Pages9384-9388
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume12
Issue number46
Early online date08 Oct 2014
DOIs
Publication statusPublished - 2014
Externally publishedYes

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remote control
Deprotonation
methylation
Methylation
Remote control
Conformations
Hydrogen
switches
Switches
stimuli
Hydrogen bonds
hydrogen bonds
synthesis
biphenylacetylene

Cite this

Knipe, Peter C. ; Jones, Ian M. ; Thompson, Sam ; Hamilton, Andrew D. / Remote conformational control of a molecular switch via methylation and deprotonation. In: Organic and Biomolecular Chemistry. 2014 ; Vol. 12, No. 46. pp. 9384-9388.
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Remote conformational control of a molecular switch via methylation and deprotonation. / Knipe, Peter C.; Jones, Ian M.; Thompson, Sam; Hamilton, Andrew D.

In: Organic and Biomolecular Chemistry, Vol. 12, No. 46, 2014, p. 9384-9388.

Research output: Contribution to journalArticle

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