Remote conformational control of a molecular switch via methylation and deprotonation

Peter C. Knipe; Ian M. Jones; Sam Thompson; Andrew D. Hamilton

doi:10.1039/c4ob01991a

Remote conformational control of a molecular switch via methylation and deprotonation

Peter C. Knipe
, Ian M. Jones
, Sam Thompson^*
, Andrew D. Hamilton

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Exacting control over conformation in response to an external stimulus is the central focus of molecular switching. Here we describe the synthesis of a series of diphenylacetylene-based molecular switches, and examine their response to covalent modification and deprotonation at remote phenolic positions. A complex interplay between multiple intramolecular hydrogen bond donors and acceptors determines the global conformation.

Original language	English
Pages (from-to)	9384-9388
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	12
Issue number	46
Early online date	08 Oct 2014
DOIs	https://doi.org/10.1039/c4ob01991a
Publication status	Published - 2014
Externally published	Yes

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Organic Chemistry
Biochemistry
General Medicine

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Cite this

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title = "Remote conformational control of a molecular switch via methylation and deprotonation",

abstract = "Exacting control over conformation in response to an external stimulus is the central focus of molecular switching. Here we describe the synthesis of a series of diphenylacetylene-based molecular switches, and examine their response to covalent modification and deprotonation at remote phenolic positions. A complex interplay between multiple intramolecular hydrogen bond donors and acceptors determines the global conformation. ",

author = "Knipe, \{Peter C.\} and Jones, \{Ian M.\} and Sam Thompson and Hamilton, \{Andrew D.\}",

year = "2014",

doi = "10.1039/c4ob01991a",

language = "English",

volume = "12",

pages = "9384--9388",

journal = "Organic and Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Remote conformational control of a molecular switch via methylation and deprotonation

AU - Knipe, Peter C.

AU - Jones, Ian M.

AU - Thompson, Sam

AU - Hamilton, Andrew D.

PY - 2014

Y1 - 2014

N2 - Exacting control over conformation in response to an external stimulus is the central focus of molecular switching. Here we describe the synthesis of a series of diphenylacetylene-based molecular switches, and examine their response to covalent modification and deprotonation at remote phenolic positions. A complex interplay between multiple intramolecular hydrogen bond donors and acceptors determines the global conformation.

AB - Exacting control over conformation in response to an external stimulus is the central focus of molecular switching. Here we describe the synthesis of a series of diphenylacetylene-based molecular switches, and examine their response to covalent modification and deprotonation at remote phenolic positions. A complex interplay between multiple intramolecular hydrogen bond donors and acceptors determines the global conformation.

UR - https://www.scopus.com/pages/publications/84908636863

U2 - 10.1039/c4ob01991a

DO - 10.1039/c4ob01991a

M3 - Article

C2 - 25317972

AN - SCOPUS:84908636863

SN - 1477-0520

VL - 12

SP - 9384

EP - 9388

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 46

ER -

Remote conformational control of a molecular switch via methylation and deprotonation

Abstract

ASJC Scopus subject areas

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