Reprogramming towards endothelial cells for vascular regeneration

Xuechong Hong, Alexandra Le Bras, Andriana Margariti, Qingbo Xu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)
205 Downloads (Pure)

Abstract

Endothelial damage and dysfunction are implicated in cardiovascular pathological changes and the development of vascular diseases. In view of the fact that the spontaneous endothelial cell (EC) regeneration is a slow and insufficient process, it is of great significance to explore alternative cell sources capable of generating functional ECs to repair damaged endothelium. Indeed, recent achievements of cell reprogramming to convert somatic cells to other cell types provide new powerful approaches to study endothelial regeneration. Based on progress in the research field, the present review aims to summarize the strategies and mechanisms of generating endothelial cells through reprogramming from somatic cells, and to examine what this means for the potential application of cell therapy in the clinic.

Original languageEnglish
Pages (from-to)186-197
Number of pages14
JournalGenes and Diseases
Volume3
Issue number3
Early online date27 Feb 2016
DOIs
Publication statusPublished - Sep 2016

Keywords

  • Atherosclerosis
  • Cell reprogramming
  • Endothelial cells
  • Endothelial regeneration
  • IPS cells
  • Stem cells

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Genetics(clinical)

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