RES-18-471.R2 - Invited Review Series: Paediatric and Adult Bronchiectasis - Airways Clearance, Muco-active therapies and Pulmonary Rehabilitation

Katherine O'Neill, Anne E O'Donnell, Judy Bradley

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

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Abstract

This paper aims to provide physiological rationale for airway clearance, mucoactive therapy and pulmonary rehabilitation (PR) (or exercise interventions) in bronchiectasis.

There is increasing emphasis on the role of Airway clearance techniques (ACTs) in the management of bronchiectasis. No single ACT has currently shown superior effect over another. Given the large range of different techniques available, consideration of the physiological effects underpinning a technique including expiratory flow, ventilation and oscillation, are essential to effectively personalise ACTs.

Key clinical trials of mucoactives in bronchiectasis are underway and will provide clarity on the role of these agents in the management of patients with bronchiectasis. Prescription of mucoactive therapies should be done in conjunction with ACTs and therefore the mechanism of action of mucoactive drugs and their timing with ACTs should be taken into consideration.

PR and/or exercise training are recommended in all current bronchiectasis guidelines. There is a clear physiologic rationale that muscle weakness and physical inactivity may play a role in disease progression as well as impacting on health related quality of life, frequency of pulmonary exacerbations and ability to mobilize sputum. However, there are residual unanswered questions surrounding the delivery and accessibility to PR.
This review summarises the physiological principles and supporting evidence for airway clearance, mucoactive medication and PR, which are key components in the management of bronchiectasis.
Original languageEnglish
Title of host publicationRespirology
EditorsAdam T Hill, Anne B Chang
PublisherWiley-Blackwell
Volume24
Publication statusAccepted - 27 Nov 2018

Keywords

  • Bronchiectasis
  • airway clearance
  • mucoactives
  • pulmonary
  • rehabilitation

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