Research in Progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK)

Liam G Heaney, Ratko Djukanovic, Ashley Woodcock, Samantha Walker, John G Matthews, Ian D Pavord, Peter Bradding, Robert Niven, Chris E Brightling, Rekha Chaudhuri, Joseph R Arron, David F Choy, Douglas Cowan, Adel Mansur, Andrew Menzies-Gow, Ian Adcock, Kian F Chung, Chris Corrigan, Peter Coyle, Timothy HarrisonSebastian Johnston, Peter Howarth, James Lordan, Ian Sabroe, Jeannette Bigler, Dirk Smith, Matthew Catley, Richard May, Lisa Pierre, Chris Stevenson, Glenn Crater, Frank Keane, Richard W Costello, Val Hudson, David Supple, Tim Hardman

Research output: Contribution to journalReview article

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Abstract

The UK Refractory Asthma Stratification Programme(RASP-UK) will explore novel biomarker stratificationstrategies in severe asthma to improve clinicalmanagement and accelerate development of newtherapies. Prior asthma mechanistic studies have notstratified on inflammatory phenotype and theunderstanding of pathophysiological mechanisms inasthma without Type 2 cytokine inflammation is limited.RASP-UK will objectively assess adherence tocorticosteroids (CS) and examine a novel compositebiomarker strategy to optimise CS dose; this will alsoaddress what proportion of patients with severe asthmahave persistent symptoms without eosinophilic airwaysinflammation after progressive CS withdrawal. There will be interactive partnership with the pharmaceutical industry to facilitate access to stratified populations for novel therapeutic studies.
Original languageEnglish
Pages (from-to)1587-189
Number of pages3
JournalThorax
Volume71
Issue number2
Early online date23 Jul 2015
DOIs
Publication statusPublished - 23 Jul 2015

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    Heaney, L. G., Djukanovic, R., Woodcock, A., Walker, S., Matthews, J. G., Pavord, I. D., Bradding, P., Niven, R., Brightling, C. E., Chaudhuri, R., Arron, J. R., Choy, D. F., Cowan, D., Mansur, A., Menzies-Gow, A., Adcock, I., Chung, K. F., Corrigan, C., Coyle, P., ... Hardman, T. (2015). Research in Progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK). Thorax, 71(2), 1587-189. https://doi.org/10.1136/thoraxjnl-2015-207326