Resistance mechanisms to cancer chemotherapy

K.M. Redmond; T.R. Wilson; Patrick Johnston; Daniel Longley

doi:10.2741/3070

Resistance mechanisms to cancer chemotherapy

K.M. Redmond, T.R. Wilson, Patrick Johnston, Daniel Longley

Research output: Contribution to journal › Article › peer-review

100 Citations (Scopus)

Abstract

Resistance to chemotherapy ('drug resistance') is a fundamental problem that limits the effectiveness of many chemotherapies currently used to treat cancer. Drug resistance can occur due to a variety of mechanisms, such as increased drug inactivation, drug efflux from cancer cells, enhanced repair of chemotherapy-induced damage, activation of pro-survival pathways and inactivation of cell death pathways. In this article, we review some of the major mechanisms of drug resistance and discuss how new molecularly-targeted therapies are being increasingly used to overcome these resistance mechanisms.

Original language	English
Pages (from-to)	5138-5154
Number of pages	17
Journal	Frontiers in Biosciences
Volume	13
Issue number	13
DOIs	https://doi.org/10.2741/3070
Publication status	Published - 2008

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology
Biochemistry
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2741/3070

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title = "Resistance mechanisms to cancer chemotherapy",

abstract = "Resistance to chemotherapy ('drug resistance') is a fundamental problem that limits the effectiveness of many chemotherapies currently used to treat cancer. Drug resistance can occur due to a variety of mechanisms, such as increased drug inactivation, drug efflux from cancer cells, enhanced repair of chemotherapy-induced damage, activation of pro-survival pathways and inactivation of cell death pathways. In this article, we review some of the major mechanisms of drug resistance and discuss how new molecularly-targeted therapies are being increasingly used to overcome these resistance mechanisms.",

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AU - Longley, Daniel

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AB - Resistance to chemotherapy ('drug resistance') is a fundamental problem that limits the effectiveness of many chemotherapies currently used to treat cancer. Drug resistance can occur due to a variety of mechanisms, such as increased drug inactivation, drug efflux from cancer cells, enhanced repair of chemotherapy-induced damage, activation of pro-survival pathways and inactivation of cell death pathways. In this article, we review some of the major mechanisms of drug resistance and discuss how new molecularly-targeted therapies are being increasingly used to overcome these resistance mechanisms.

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Resistance mechanisms to cancer chemotherapy

Abstract

ASJC Scopus subject areas

UN SDGs

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