Resistance mechanisms to cancer chemotherapy

K.M. Redmond, T.R. Wilson, Patrick Johnston, Daniel Longley

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Resistance to chemotherapy ('drug resistance') is a fundamental problem that limits the effectiveness of many chemotherapies currently used to treat cancer. Drug resistance can occur due to a variety of mechanisms, such as increased drug inactivation, drug efflux from cancer cells, enhanced repair of chemotherapy-induced damage, activation of pro-survival pathways and inactivation of cell death pathways. In this article, we review some of the major mechanisms of drug resistance and discuss how new molecularly-targeted therapies are being increasingly used to overcome these resistance mechanisms.
Original languageEnglish
Pages (from-to)5138-5154
Number of pages17
JournalFrontiers in Biosciences
Volume13
Issue number13
DOIs
Publication statusPublished - 2008

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Chemotherapy
Drug Resistance
Drug Therapy
Pharmaceutical Preparations
Neoplasms
Cell Death
Cell death
Repair
Chemical activation
Cells
Therapeutics

Cite this

Redmond, K. M., Wilson, T. R., Johnston, P., & Longley, D. (2008). Resistance mechanisms to cancer chemotherapy. Frontiers in Biosciences, 13(13), 5138-5154. https://doi.org/10.2741/3070
Redmond, K.M. ; Wilson, T.R. ; Johnston, Patrick ; Longley, Daniel. / Resistance mechanisms to cancer chemotherapy. In: Frontiers in Biosciences. 2008 ; Vol. 13, No. 13. pp. 5138-5154.
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Redmond, KM, Wilson, TR, Johnston, P & Longley, D 2008, 'Resistance mechanisms to cancer chemotherapy', Frontiers in Biosciences, vol. 13, no. 13, pp. 5138-5154. https://doi.org/10.2741/3070

Resistance mechanisms to cancer chemotherapy. / Redmond, K.M.; Wilson, T.R.; Johnston, Patrick; Longley, Daniel.

In: Frontiers in Biosciences, Vol. 13, No. 13, 2008, p. 5138-5154.

Research output: Contribution to journalArticle

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