Resistance mechanisms to cancer chemotherapy

K.M. Redmond, T.R. Wilson, Patrick Johnston, Daniel Longley

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Resistance to chemotherapy ('drug resistance') is a fundamental problem that limits the effectiveness of many chemotherapies currently used to treat cancer. Drug resistance can occur due to a variety of mechanisms, such as increased drug inactivation, drug efflux from cancer cells, enhanced repair of chemotherapy-induced damage, activation of pro-survival pathways and inactivation of cell death pathways. In this article, we review some of the major mechanisms of drug resistance and discuss how new molecularly-targeted therapies are being increasingly used to overcome these resistance mechanisms.
Original languageEnglish
Pages (from-to)5138-5154
Number of pages17
JournalFrontiers in Biosciences
Volume13
Issue number13
DOIs
Publication statusPublished - 2008

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

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