Respiratory syncytial virus interaction with human airway epithelium

Remi Villenave, Michael D Shields, Ultan F Power

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Although respiratory syncytial virus (RSV) is a major human respiratory pathogen, our knowledge of how it causes disease in humans is limited. Airway epithelial cells are the primary targets of RSV infection in vivo, so the generation and exploitation of RSV infection models based on morphologically and physiologically authentic well-differentiated primary human airway epithelial cells cultured at an air-liquid interface (WD-PAECs) provide timely developments that will help to bridge this gap. Here we review the interaction of RSV with WD-PAEC cultures, the authenticity of the RSV-WD-PAEC models relative to RSV infection of human airway epithelium in vivo, and future directions for their exploitation in our quest to understand RSV pathogenesis in humans.
Original languageEnglish
Pages (from-to)238-44
JournalTrends in microbiology
Volume21
Issue number5
DOIs
Publication statusPublished - May 2013

Bibliographical note

Copyright © 2013 Elsevier Ltd. All rights reserved.

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Microbiology
  • Virology

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