Response of vulval lichen sclerosus and squamous hyperplasia to photodynamic treatment using sustained topical delivery of aminolevulinic acid from a novel bioadhesive patch system

Ryan Donnelly; A.A. Zawislak; W.G. McCluggage; P. Maxwell; J.H. Price; S.P. Dobbs; H.R. McClelland; David Woolfson; P.A. McCarron

doi:10.1111/j.1600-0781.2009.00410.x

Response of vulval lichen sclerosus and squamous hyperplasia to photodynamic treatment using sustained topical delivery of aminolevulinic acid from a novel bioadhesive patch system

Ryan Donnelly, A.A. Zawislak, W.G. McCluggage, P. Maxwell, J.H. Price, S.P. Dobbs, H.R. McClelland, David Woolfson, P.A. McCarron

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

This study evaluated the clinical and histopathological responses of vulval lichen sclerosus (LS) and squamous hyperplasia (SH) to photodynamic therapy (PDT). A novel bioadhesive patch containing aminolevulinic acid (ALA) at a dose of (38 mg/cm(2)) was used to treat 10 patients before irradiation with light of 630 nm. Clinical, histopathological and pathological responses to treatment were assessed at 6 weeks post-treatment. After 17 cycles of PDT, six patients reported significant symptomatic relief and no cutaneous photosensitivity. Histopathological differences were not demonstrated, but statistically significant induction of apoptosis was seen. It can be concluded that ALA-PDT patch-based formulation is pragmatic and primarily offers symptomatic management of vulval LS and SH.

Original language	English
Pages (from-to)	111-113
Number of pages	3
Journal	Photodermatology, Photoimmunology & Photomedicine
Volume	25
Issue number	2
DOIs	https://doi.org/10.1111/j.1600-0781.2009.00410.x
Publication status	Published - Apr 2009

ASJC Scopus subject areas

Dermatology
Immunology and Allergy
Immunology
Radiology Nuclear Medicine and imaging

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10.1111/j.1600-0781.2009.00410.x

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Donnelly, R., Zawislak, A. A., McCluggage, W. G., Maxwell, P., Price, J. H., Dobbs, S. P., McClelland, H. R., Woolfson, D., & McCarron, P. A. (2009). Response of vulval lichen sclerosus and squamous hyperplasia to photodynamic treatment using sustained topical delivery of aminolevulinic acid from a novel bioadhesive patch system. Photodermatology, Photoimmunology & Photomedicine, 25(2), 111-113. https://doi.org/10.1111/j.1600-0781.2009.00410.x

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title = "Response of vulval lichen sclerosus and squamous hyperplasia to photodynamic treatment using sustained topical delivery of aminolevulinic acid from a novel bioadhesive patch system",

abstract = "This study evaluated the clinical and histopathological responses of vulval lichen sclerosus (LS) and squamous hyperplasia (SH) to photodynamic therapy (PDT). A novel bioadhesive patch containing aminolevulinic acid (ALA) at a dose of (38 mg/cm(2)) was used to treat 10 patients before irradiation with light of 630 nm. Clinical, histopathological and pathological responses to treatment were assessed at 6 weeks post-treatment. After 17 cycles of PDT, six patients reported significant symptomatic relief and no cutaneous photosensitivity. Histopathological differences were not demonstrated, but statistically significant induction of apoptosis was seen. It can be concluded that ALA-PDT patch-based formulation is pragmatic and primarily offers symptomatic management of vulval LS and SH.",

author = "Ryan Donnelly and A.A. Zawislak and W.G. McCluggage and P. Maxwell and J.H. Price and S.P. Dobbs and H.R. McClelland and David Woolfson and P.A. McCarron",

year = "2009",

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language = "English",

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Donnelly, R, Zawislak, AA, McCluggage, WG, Maxwell, P, Price, JH, Dobbs, SP, McClelland, HR, Woolfson, D & McCarron, PA 2009, 'Response of vulval lichen sclerosus and squamous hyperplasia to photodynamic treatment using sustained topical delivery of aminolevulinic acid from a novel bioadhesive patch system', Photodermatology, Photoimmunology & Photomedicine, vol. 25, no. 2, pp. 111-113. https://doi.org/10.1111/j.1600-0781.2009.00410.x

Response of vulval lichen sclerosus and squamous hyperplasia to photodynamic treatment using sustained topical delivery of aminolevulinic acid from a novel bioadhesive patch system. / Donnelly, Ryan; Zawislak, A.A.; McCluggage, W.G. et al.
In: Photodermatology, Photoimmunology & Photomedicine, Vol. 25, No. 2, 04.2009, p. 111-113.

Research output: Contribution to journal › Article › peer-review

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AU - Donnelly, Ryan

AU - Zawislak, A.A.

AU - McCluggage, W.G.

AU - Maxwell, P.

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AB - This study evaluated the clinical and histopathological responses of vulval lichen sclerosus (LS) and squamous hyperplasia (SH) to photodynamic therapy (PDT). A novel bioadhesive patch containing aminolevulinic acid (ALA) at a dose of (38 mg/cm(2)) was used to treat 10 patients before irradiation with light of 630 nm. Clinical, histopathological and pathological responses to treatment were assessed at 6 weeks post-treatment. After 17 cycles of PDT, six patients reported significant symptomatic relief and no cutaneous photosensitivity. Histopathological differences were not demonstrated, but statistically significant induction of apoptosis was seen. It can be concluded that ALA-PDT patch-based formulation is pragmatic and primarily offers symptomatic management of vulval LS and SH.

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Donnelly R, Zawislak AA, McCluggage WG, Maxwell P, Price JH, Dobbs SP et al. Response of vulval lichen sclerosus and squamous hyperplasia to photodynamic treatment using sustained topical delivery of aminolevulinic acid from a novel bioadhesive patch system. Photodermatology, Photoimmunology & Photomedicine. 2009 Apr;25(2):111-113. doi: 10.1111/j.1600-0781.2009.00410.x

Response of vulval lichen sclerosus and squamous hyperplasia to photodynamic treatment using sustained topical delivery of aminolevulinic acid from a novel bioadhesive patch system

Abstract

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