Response to Park et al. reply to "Back to the future: routine morphological assessment of the tumour microenvironment is prognostic in stage II/III colon cancer in a large population-based study"

Seán O Hynes, Helen G Coleman, Paul J Kelly, Philip D Dunne, Manuel Salto-Tellez, Maurice B Loughrey

Research output: Contribution to journalArticle

1 Citation (Scopus)
264 Downloads (Pure)

Abstract

We thank Park et al for their interest in our work and for bringing to our attention their alternative microenvironmental score for assessing colorectal cancer prognosis. (1-3) We are largely in agreement with many of the points raised. The scoring systems proposed by these two studies share many similarities, highlighting the importance of the non-epithelial tumour components and combining assessments of peritumoral inflammatory response and tumour stromal percentage to derive a prognostically valuable fibroinflammatory or microenvironmental score. Despite the overall similarity, a number of small, albeit clinically important, differences lie in the methodologies chosen for assessment of each individual parameter, and in the statistical approaches used.

Original languageEnglish
JournalHistopathology
Early online date23 Mar 2017
DOIs
Publication statusEarly online date - 23 Mar 2017

Keywords

  • Letter

Fingerprint Dive into the research topics of 'Response to Park et al. reply to "Back to the future: routine morphological assessment of the tumour microenvironment is prognostic in stage II/III colon cancer in a large population-based study"'. Together they form a unique fingerprint.

Cite this