Retinal biomarker discovery for dementia in an elderly diabetic population

Ahmed E. Fetit*, Siyamalan Manivannan, Sarah McGrory, Lucia Ballerini, Alexander Doney, Thomas J. MacGillivray, Ian J. Deary, Joanna M. Wardlaw, Fergus Doubal, Gareth J. McKay, Stephen J. McKenna, Emanuele Trucco

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Abstract

Dementia is a devastating disease, and has severe implications on affected individuals, their family and wider society. A growing body of literature is studying the association of retinal microvasculature measurement with dementia. We present a pilot study testing the strength of groups of conventional (semantic) and texture-based (non-semantic) measurements extracted from retinal fundus camera images to classify patients with and without dementia. We performed a 500-trial bootstrap analysis with regularized logistic regression on a cohort of 1,742 elderly diabetic individuals (median age 72.2). Age was the strongest predictor for this elderly cohort. Semantic retinal measurements featured in up to 81% of the bootstrap trials, with arterial caliber and optic disk size chosen most often, suggesting that they do complement age when selected together in a classifier. Textural features were able to train classifiers that match the performance of age, suggesting they are potentially a rich source of information for dementia outcome classification.

Original languageEnglish
Title of host publicationFetal, Infant and Ophthalmic Medical Image Analysis - International Workshop, FIFI 2017 and 4th International Workshop, OMIA 2017 Held in Conjunction with MICCAI 2017, Proceedings
PublisherSpringer Verlag
Pages150-158
Number of pages9
Volume10554 LNCS
ISBN (Print)9783319675602
DOIs
Publication statusPublished - 09 Sep 2017
EventInternational Workshop on Fetal and Infant Image Analysis, FIFI 2017 and 4th International Workshop on Ophthalmic Medical Image Analysis, OMIA 2017 held in Conjunction with 20th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2017 - Quebec City, Canada
Duration: 14 Sep 201714 Sep 2017

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume10554
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

ConferenceInternational Workshop on Fetal and Infant Image Analysis, FIFI 2017 and 4th International Workshop on Ophthalmic Medical Image Analysis, OMIA 2017 held in Conjunction with 20th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2017
CountryCanada
CityQuebec City
Period14/09/201714/09/2017

Fingerprint

Dementia
Biomarkers
Classifiers
Semantics
Bootstrap
Classifier
Logistics
Optics
Logistic Regression
Textures
Cameras
Association reactions
Texture
Predictors
Complement
Camera
Classify
Testing

Keywords

  • Biomarkers
  • Classification
  • Dementia
  • Microvasculature
  • Retina

Cite this

Fetit, A. E., Manivannan, S., McGrory, S., Ballerini, L., Doney, A., MacGillivray, T. J., ... Trucco, E. (2017). Retinal biomarker discovery for dementia in an elderly diabetic population. In Fetal, Infant and Ophthalmic Medical Image Analysis - International Workshop, FIFI 2017 and 4th International Workshop, OMIA 2017 Held in Conjunction with MICCAI 2017, Proceedings (Vol. 10554 LNCS, pp. 150-158). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 10554). Springer Verlag. https://doi.org/10.1007/978-3-319-67561-9_17
Fetit, Ahmed E. ; Manivannan, Siyamalan ; McGrory, Sarah ; Ballerini, Lucia ; Doney, Alexander ; MacGillivray, Thomas J. ; Deary, Ian J. ; Wardlaw, Joanna M. ; Doubal, Fergus ; McKay, Gareth J. ; McKenna, Stephen J. ; Trucco, Emanuele. / Retinal biomarker discovery for dementia in an elderly diabetic population. Fetal, Infant and Ophthalmic Medical Image Analysis - International Workshop, FIFI 2017 and 4th International Workshop, OMIA 2017 Held in Conjunction with MICCAI 2017, Proceedings. Vol. 10554 LNCS Springer Verlag, 2017. pp. 150-158 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).
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Fetit, AE, Manivannan, S, McGrory, S, Ballerini, L, Doney, A, MacGillivray, TJ, Deary, IJ, Wardlaw, JM, Doubal, F, McKay, GJ, McKenna, SJ & Trucco, E 2017, Retinal biomarker discovery for dementia in an elderly diabetic population. in Fetal, Infant and Ophthalmic Medical Image Analysis - International Workshop, FIFI 2017 and 4th International Workshop, OMIA 2017 Held in Conjunction with MICCAI 2017, Proceedings. vol. 10554 LNCS, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 10554, Springer Verlag, pp. 150-158, International Workshop on Fetal and Infant Image Analysis, FIFI 2017 and 4th International Workshop on Ophthalmic Medical Image Analysis, OMIA 2017 held in Conjunction with 20th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2017, Quebec City, Canada, 14/09/2017. https://doi.org/10.1007/978-3-319-67561-9_17

Retinal biomarker discovery for dementia in an elderly diabetic population. / Fetit, Ahmed E.; Manivannan, Siyamalan; McGrory, Sarah; Ballerini, Lucia; Doney, Alexander; MacGillivray, Thomas J.; Deary, Ian J.; Wardlaw, Joanna M.; Doubal, Fergus; McKay, Gareth J.; McKenna, Stephen J.; Trucco, Emanuele.

Fetal, Infant and Ophthalmic Medical Image Analysis - International Workshop, FIFI 2017 and 4th International Workshop, OMIA 2017 Held in Conjunction with MICCAI 2017, Proceedings. Vol. 10554 LNCS Springer Verlag, 2017. p. 150-158 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 10554).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AU - MacGillivray, Thomas J.

AU - Deary, Ian J.

AU - Wardlaw, Joanna M.

AU - Doubal, Fergus

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AU - McKenna, Stephen J.

AU - Trucco, Emanuele

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Fetit AE, Manivannan S, McGrory S, Ballerini L, Doney A, MacGillivray TJ et al. Retinal biomarker discovery for dementia in an elderly diabetic population. In Fetal, Infant and Ophthalmic Medical Image Analysis - International Workshop, FIFI 2017 and 4th International Workshop, OMIA 2017 Held in Conjunction with MICCAI 2017, Proceedings. Vol. 10554 LNCS. Springer Verlag. 2017. p. 150-158. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). https://doi.org/10.1007/978-3-319-67561-9_17