Abstract
BACKGROUND: Retinal ischaemia is present to a greater or lesser extent in all eyes with diabetic retinopathy (DR). Nonetheless, our understanding of its pathogenic mechanisms, risk factors, as well as other characteristics of retinal ischaemia in DR is very limited. To date, there is no treatment to revascularise ischaemic retina.
METHODS: Review of the literature highlighting the current knowledge on the topic of retinal ischaemia in DR, important observations made, and underlying gaps for which research is needed.
RESULTS: A very scarce number of clinical studies, mostly cross-sectional, have evaluated specifically retinal ischaemia in DR. Interindividual variability on its natural course and consequences, including the development of its major complications, namely diabetic macular ischaemia and proliferative diabetic retinopathy, have not been investigated. The in situ, surrounding, and distance effect of retinal ischaemia on retinal function and structure and its change over time remains also to be elucidated. Treatments to prevent the development of retinal ischaemia and, importantly, to achieve retinal reperfusion once capillary drop out has ensued, are very much needed and remain to be developed.
CONCLUSION: Research into retinal ischaemia in diabetes should be a priority to save sight.
Original language | English |
---|---|
Article number | 2406 |
Journal | Journal of Clinical Medicine |
Volume | 12 |
Issue number | 6 |
DOIs | |
Publication status | Published - 21 Mar 2023 |
Bibliographical note
Funding Information:This research was funded by the generous contribution of Elizabeth Sloan.
Publisher Copyright:
© 2023 by the authors.
Keywords
- diabetes
- diabetic macular ischaemia
- diabetic retinopathy
- DMI
- DR
- FFA
- OCT
- OCT angiography
- OCTA
- optical coherence tomography angiography
- retinal capillary dropout
- retinal function
- retinal ischaemia
- retinal nonperfusion
- ultra-widefield fluorescein angiography
- UWF FFA
ASJC Scopus subject areas
- General Medicine
Fingerprint
Dive into the research topics of 'Retinal ischaemia in diabetic retinopathy: understanding and overcoming a therapeutic challenge: understanding and overcoming a therapeutic challenge'. Together they form a unique fingerprint.Student theses
-
Identification of prognastic factors for development and progression of prolifative diabetic retinopathy
Hamilton-Perais, J. A. (Author), Lois, N. (Supervisor), Hogg, R. (Supervisor) & Lawrenson, J. (Supervisor), Jul 2024Student thesis: Doctoral Thesis › Doctor of Philosophy