Retinal vascular geometry predicts incident renal dysfunction in young people with type 1 diabetes

P.Z. Benitez-Aguirre, M.E. Craig, J. Cusumano, A.J. Jenkins, K.C. Donaghue, M.B. Sasongko, N. Cheung, T.Y. Wong

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE - To examine the relationship between retinal vascular geometry parameters and development of incident renal dysfunction in young people with type 1 diabetes. RESEARCH DESIGN AND METHODS - This was a prospective cohort study of 511 adolescents with type 1 diabetes of at least 2 years duration, with normal albumin excretion rate (AER) and no retinopathy at baseline while attending an Australian tertiary-care hospital. AER was quantified using three overnight, timed urine specimen collections and early renal dysfunction was defined as AER >7.5 µg/min. Retinal vascular geometry (including length-to-diameter ratio [LDR] and simple tortuosity [ST]) was quantified from baseline retinal photographs. Generalized estimating equations were used to examine the relationship between incident renal dysfunction and baseline venular LDR and ST, adjusting for age, diabetes duration, glycated hemoglobin (A1C), blood pressure (BP), BMI, and cholesterol. RESULTS - Diabetes duration at baseline was 4.8 (IQR 3.3-7.5) years. After amedian 3.7 (2.3-5.7) years follow-up, 34% of participants developed incident renal dysfunction. In multivariate analysis, higher retinal venular LDR (odds ratio 1.7, 95% CI 1.2-2.4; quartile 4 vs. 1-3) and lower venular ST (1.6, 1.1-2.2; quartile 1 vs. 2-4) predicted incident renal dysfunction. CONCLUSIONS - Retinal venular geometry independently predicted incident renal dysfunction in young people with type 1 diabetes. These noninvasive retinal measures may help to elucidate early mechanistic pathways for microvascular complications. Retinal venular geometry may be a useful tool to identify individuals at high risk of renal disease early in the course of diabetes.
Original languageEnglish
Pages (from-to)599-604
Number of pages6
JournalDiabetes Care
Volume35
Issue number3
DOIs
Publication statusPublished - 01 Mar 2012

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Retinal Vessels
Type 1 Diabetes Mellitus
Kidney
Albumins
Urine Specimen Collection
Glycosylated Hemoglobin A
Tertiary Healthcare
Tertiary Care Centers
Cohort Studies
Research Design
Multivariate Analysis
Odds Ratio
Cholesterol
Prospective Studies
Blood Pressure

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Benitez-Aguirre, P. Z., Craig, M. E., Cusumano, J., Jenkins, A. J., Donaghue, K. C., Sasongko, M. B., ... Wong, T. Y. (2012). Retinal vascular geometry predicts incident renal dysfunction in young people with type 1 diabetes. Diabetes Care, 35(3), 599-604. https://doi.org/10.2337/dc11-1177
Benitez-Aguirre, P.Z. ; Craig, M.E. ; Cusumano, J. ; Jenkins, A.J. ; Donaghue, K.C. ; Sasongko, M.B. ; Cheung, N. ; Wong, T.Y. / Retinal vascular geometry predicts incident renal dysfunction in young people with type 1 diabetes. In: Diabetes Care. 2012 ; Vol. 35, No. 3. pp. 599-604.
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Benitez-Aguirre, PZ, Craig, ME, Cusumano, J, Jenkins, AJ, Donaghue, KC, Sasongko, MB, Cheung, N & Wong, TY 2012, 'Retinal vascular geometry predicts incident renal dysfunction in young people with type 1 diabetes', Diabetes Care, vol. 35, no. 3, pp. 599-604. https://doi.org/10.2337/dc11-1177

Retinal vascular geometry predicts incident renal dysfunction in young people with type 1 diabetes. / Benitez-Aguirre, P.Z.; Craig, M.E.; Cusumano, J.; Jenkins, A.J.; Donaghue, K.C.; Sasongko, M.B.; Cheung, N.; Wong, T.Y.

In: Diabetes Care, Vol. 35, No. 3, 01.03.2012, p. 599-604.

Research output: Contribution to journalArticle

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Benitez-Aguirre PZ, Craig ME, Cusumano J, Jenkins AJ, Donaghue KC, Sasongko MB et al. Retinal vascular geometry predicts incident renal dysfunction in young people with type 1 diabetes. Diabetes Care. 2012 Mar 1;35(3):599-604. https://doi.org/10.2337/dc11-1177