Retinopathy risk calculators in the prediction of sight-threatening diabetic retinopathy in type 2 diabetes: a FIELD substudy

Benjamin N. Rao, Nicola Quinn, Andrzej S. Januszewski, Tunde Peto, Laima Brazionis, Nanda Aryal, Rachel L. O'Connell, Liping Li, Paula Summanen, Russell Scott, Justin O'Day, Anthony C. Keech, Alicia J. Jenkins*, FIELD Study Group

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Aims
To evaluate the risk algorithm by Aspelund et al. for predicting sight-threatening diabetic retinopathy (STDR) in Type 2 diabetes (T2D), and to develop a new STDR prediction model.

Methods
The Aspelund et al. algorithm was used to calculate STDR risk from baseline variables in 1012 participants in the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) ophthalmological substudy, compared to on-trial STDR status, and receiver operating characteristic analysis performed. Using multivariable logistic regression, traditional risk factors and fenofibrate allocation as STDR predictors were evaluated, with bootstrap-based optimism-adjusted estimates of predictive performance calculated.

Results
STDR developed in 28 participants. The Aspelund et al. algorithm predicted STDR at 2- and 5-years with area under the curve (AUC) 0.86 (95% CI 0.77–0.94) and 0.86 (0.81–0.92), respectively. In the second model STDR risk factors were any DR at baseline (OR 24.0 [95% CI 5.53–104]), HbA1c (OR 1.95 [1.43–2.64]) and male sex (OR 4.34 [1.32–14.3]), while fenofibrate (OR 0.13 [0.05–0.38]) was protective. This model had excellent discriminatory ability (AUC = 0.89).

Conclusions
The algorithm by Aspelund et al. predicts STDR well in the FIELD ophthalmology substudy. Logistic regression analysis found DR at baseline, male sex, and HbA1c were predictive of STDR and, fenofibrate was protective.

Original languageEnglish
Article number109835
Number of pages6
JournalDiabetes Research and Clinical Practice
Volume186
Early online date28 Mar 2022
DOIs
Publication statusPublished - Apr 2022

Keywords

  • Validation study
  • Risk calculator
  • Fenofibrate
  • Diabetic retinopathy

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