Reversible Photocontrol of Deoxyribozyme-Catalyzed RNA Cleavage under Multiple-Turnover Conditions

S. Keiper, Joseph Vyle

Research output: Contribution to journalArticlepeer-review

70 Citations (Scopus)
295 Downloads (Pure)

Abstract

Lights, camera, action! Photoswitchable nucleoside analogues containing o-, m-, or p-azobenzenes can be inserted in the catalytic core of RNA-cleaving 10-23 deoxyribozymes by replacing a nonconserved residue (see picture). Irradiation of the modified deoxyribozymes at 366 nm enhances RNA cleavage rates up to ninefold, thus achieving the rates observed for the unmodified deoxyribozyme.
Original languageEnglish
Pages (from-to)3306-3309
Number of pages4
JournalAngewandte Chemie International Edition
Volume45
Issue number20
DOIs
Publication statusPublished - 12 Apr 2006

ASJC Scopus subject areas

  • Chemistry(all)

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