Revisiting glucose uptake and metabolism in schistosomes: New molecular insights for improved schistosomiasis therapies

Hong You*, Rachel J. Stephenson, Geoffrey N. Gobert, Donald P. McManus

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

16 Citations (Scopus)
266 Downloads (Pure)

Abstract

A better understanding of the molecular mechanisms required for schistosomes to take up glucose, the major nutritional source exploited by these blood flukes from their mammalian hosts and the subsequent metabolism required to fuel growth and fecundity, can provide new avenues for developing novel interventions for the control of schistosomiasis. This aspect of parasitism is particularly important to paired adult schistosomes, due to their considerable requirements for the energy needed to produce the extensive numbers of eggs laid daily by the female worm. This review describes recent advances in characterizing glucose metabolism in adult schistosomes. Potential intervention targets are discussed within the insulin signaling and glycolysis pathways, both of which play critical roles in the carbohydrate and energy requirements of schistosomes.

Original languageEnglish
Article number176
JournalFrontiers in Genetics
Volume5
DOIs
Publication statusPublished - 11 Jun 2014

Keywords

  • Glucose uptake and metabolism
  • Glycolysis signaling pathway
  • Insulin signaling pathway
  • Schistosoma
  • Schistosome

ASJC Scopus subject areas

  • Genetics
  • Molecular Medicine
  • Genetics(clinical)

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