Abstract
A better understanding of the molecular mechanisms required for schistosomes to take up glucose, the major nutritional source exploited by these blood flukes from their mammalian hosts and the subsequent metabolism required to fuel growth and fecundity, can provide new avenues for developing novel interventions for the control of schistosomiasis. This aspect of parasitism is particularly important to paired adult schistosomes, due to their considerable requirements for the energy needed to produce the extensive numbers of eggs laid daily by the female worm. This review describes recent advances in characterizing glucose metabolism in adult schistosomes. Potential intervention targets are discussed within the insulin signaling and glycolysis pathways, both of which play critical roles in the carbohydrate and energy requirements of schistosomes.
| Original language | English |
|---|---|
| Article number | 176 |
| Journal | Frontiers in Genetics |
| Volume | 5 |
| DOIs | |
| Publication status | Published - 11 Jun 2014 |
Keywords
- Glucose uptake and metabolism
- Glycolysis signaling pathway
- Insulin signaling pathway
- Schistosoma
- Schistosome
ASJC Scopus subject areas
- Genetics
- Molecular Medicine
- Genetics(clinical)
Access to Document
- Revisiting glucose uptake and metabolism in schistosomes New molecular insights for improved schistosomiasis therapies
Copyright © 2014 You, Stephenson, Gobert and McManus. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) https://creativecommons.org/licenses/by/3.0/. The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.