Abstract
Purpose. To manufacture and characterize, through oscillatory rheology, thermoresponsive rheologically structured vehicles
(RSV’s) capable of enhanced retention times within the vagina for the purposes of HIV vaccine delivery.
Methods. Pluronics F127, F108 and F68 were investigated and RSV’s were prepared by dissolving sorbic acid (0.1% w/w)
and mucoadhesive component (Gantrez SBF97 or Noveon AA1, 3% w/w) in the required amount of H2O and NaOH.
Pluronic (10% w/w) was added via mixing in an ice-bath followed by hydroxyethylcellulose (5%) and subsequently
poly(vinylpyrollidone) (4%w/w). Oscillatory temperature sweeps between 10-38°C were preformed within the linear
viscoelastic region of the formulations on an AR2000 rheometer (T.A. Instruments, Surrey, England) with a 2cm diameter
parallel plate geometry and a plate gap of 1000µm at 1Hz.
(RSV’s) capable of enhanced retention times within the vagina for the purposes of HIV vaccine delivery.
Methods. Pluronics F127, F108 and F68 were investigated and RSV’s were prepared by dissolving sorbic acid (0.1% w/w)
and mucoadhesive component (Gantrez SBF97 or Noveon AA1, 3% w/w) in the required amount of H2O and NaOH.
Pluronic (10% w/w) was added via mixing in an ice-bath followed by hydroxyethylcellulose (5%) and subsequently
poly(vinylpyrollidone) (4%w/w). Oscillatory temperature sweeps between 10-38°C were preformed within the linear
viscoelastic region of the formulations on an AR2000 rheometer (T.A. Instruments, Surrey, England) with a 2cm diameter
parallel plate geometry and a plate gap of 1000µm at 1Hz.
| Original language | English |
|---|---|
| Pages | T2145-T2145 |
| Number of pages | 1 |
| Publication status | Published - Nov 2007 |
| Event | American Association of Pharmaceutical Scientists 2007 - Austin, United States Duration: 01 Nov 2007 → 01 Nov 2007 |
Conference
| Conference | American Association of Pharmaceutical Scientists 2007 |
|---|---|
| Country | United States |
| City | Austin |
| Period | 01/11/2007 → 01/11/2007 |
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Cite this
Malcolm, K., Andrews, G., Donnelly, L., & Woolfson, D. (2007). Rheological characterization of thermoresponsive semisolids for vaginal HIV vaccine delivery. T2145-T2145. Poster session presented at American Association of Pharmaceutical Scientists 2007, Austin, United States.