RhoA protein expression correlates positively with degree of malignancy in astrocytomas

B. Yan, H.H. Chour, B.K. Peh, C. Lim, Manuel Salto-Tellez

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

Astrocytic tumors are the most common intracranial neoplasms. Their prognoses correlate with a conventional morphological grading system that suffers from diagnostic subjectivity and hence, inter-observer inconsistency. A molecular marker that provides an objective reference for classification and prognostication of astrocytic tumors would be useful in diagnostic pathology. RhoA, a GTPase protein involved in cell migration and adhesion has been shown to be upregulated in a variety of human cancers. Based on direct analysis of clinical materials, our study demonstrates increased expression of RhoA in high-grade astrocytomas. This observation may be relevant to astrocytoma biology and the development of potential therapeutics against high-grade astrocytomas. Of more immediate consequence, utilization of this marker may aid in the routine pathological grading (and hence prognostication) of astrocytomas. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)124-126
Number of pages3
JournalNeuroscience Letters
Volume407
Issue number2
DOIs
Publication statusPublished - 23 Oct 2006

ASJC Scopus subject areas

  • Neuroscience(all)

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