Rinderpest and peste de petits ruminants viruses exhibit neurovirulence in mice

S.E. Gailbraith, S. McQuiad, T. Barrett, L. Hamill, L. Pullen, Louise Cosby

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Members of the morbillivirus genus, canine distemper (CDV), phocine distemper virus (PDV), and the cetacean viruses of dolphins and porpoises exhibit high levels of CNS infection in their natural hosts. CNS complications are rare for measles virus (MV) and are not associated with rinderpest virus (RPV) and peste des petits ruminants virus (PPRV) infection. However, it is possible that all morbilliviruses infect the CNS but in some hosts are rapidly cleared by the immune response. In this study, we assessed whether RPV and PPRV have the potential to be neurovirulent. We describe the outcome of infection, of selected mouse strains, with isolates of RPV, PPRV, PDV, porpoise morbillivirus (PMV), dolphin morbillivirus (DMV), and a wild-type strain of MV. In the case of RPV virus, strains with different passage histories have been examined. The results of experiments with these viruses were compared with those using neuroadapted and vaccine strains of MV, which acted as positive and negative controls respectively. Intracerebral inoculation with RPV (Saudi/81) and PPRV (Nigeria75/1) strains produced infection in Balb/C and Cd1, but not C57 suckling mice, whereas the CAM/RB rodent-adapted strain of MV infected all three strains of mice. Weanling mice were only infected by CAM/RB. Intranasal and intraperitoneal inoculation failed to produce infection with any virus strains. We have shown that, both RPV and PPRV, in common with other morbilliviruses are neurovirulent in a permissive system. Transient infection of the CNS of cattle and goats with RPV and PPRV, respectively, remains a possibility, which could provide relevant models for the initial stages of MV infection in humans.
Original languageEnglish
Pages (from-to)45-52
Number of pages8
JournalJournal of Neurovirology
Volume8(1)
Issue number1
DOIs
Publication statusPublished - Feb 2002

Fingerprint

Rinderpest virus
Rinderpest
Peste-des-petits-ruminants virus
Morbillivirus
Ruminants
Measles virus
Viruses
Phocine Distemper Virus
Porpoises
Dolphins
Infection
Virus Diseases
Distemper
Goats
Rodentia
Vaccines

Cite this

Gailbraith, S.E. ; McQuiad, S. ; Barrett, T. ; Hamill, L. ; Pullen, L. ; Cosby, Louise. / Rinderpest and peste de petits ruminants viruses exhibit neurovirulence in mice. In: Journal of Neurovirology. 2002 ; Vol. 8(1), No. 1. pp. 45-52.
@article{b1b90dd8b3e14992a510839657ec3c35,
title = "Rinderpest and peste de petits ruminants viruses exhibit neurovirulence in mice",
abstract = "Members of the morbillivirus genus, canine distemper (CDV), phocine distemper virus (PDV), and the cetacean viruses of dolphins and porpoises exhibit high levels of CNS infection in their natural hosts. CNS complications are rare for measles virus (MV) and are not associated with rinderpest virus (RPV) and peste des petits ruminants virus (PPRV) infection. However, it is possible that all morbilliviruses infect the CNS but in some hosts are rapidly cleared by the immune response. In this study, we assessed whether RPV and PPRV have the potential to be neurovirulent. We describe the outcome of infection, of selected mouse strains, with isolates of RPV, PPRV, PDV, porpoise morbillivirus (PMV), dolphin morbillivirus (DMV), and a wild-type strain of MV. In the case of RPV virus, strains with different passage histories have been examined. The results of experiments with these viruses were compared with those using neuroadapted and vaccine strains of MV, which acted as positive and negative controls respectively. Intracerebral inoculation with RPV (Saudi/81) and PPRV (Nigeria75/1) strains produced infection in Balb/C and Cd1, but not C57 suckling mice, whereas the CAM/RB rodent-adapted strain of MV infected all three strains of mice. Weanling mice were only infected by CAM/RB. Intranasal and intraperitoneal inoculation failed to produce infection with any virus strains. We have shown that, both RPV and PPRV, in common with other morbilliviruses are neurovirulent in a permissive system. Transient infection of the CNS of cattle and goats with RPV and PPRV, respectively, remains a possibility, which could provide relevant models for the initial stages of MV infection in humans.",
author = "S.E. Gailbraith and S. McQuiad and T. Barrett and L. Hamill and L. Pullen and Louise Cosby",
year = "2002",
month = "2",
doi = "10.1080/135502802317247802",
language = "English",
volume = "8(1)",
pages = "45--52",
journal = "Journal of Neurovirology",
issn = "1355-0284",
publisher = "Springer New York",
number = "1",

}

Rinderpest and peste de petits ruminants viruses exhibit neurovirulence in mice. / Gailbraith, S.E.; McQuiad, S.; Barrett, T.; Hamill, L.; Pullen, L.; Cosby, Louise.

In: Journal of Neurovirology, Vol. 8(1), No. 1, 02.2002, p. 45-52.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Rinderpest and peste de petits ruminants viruses exhibit neurovirulence in mice

AU - Gailbraith, S.E.

AU - McQuiad, S.

AU - Barrett, T.

AU - Hamill, L.

AU - Pullen, L.

AU - Cosby, Louise

PY - 2002/2

Y1 - 2002/2

N2 - Members of the morbillivirus genus, canine distemper (CDV), phocine distemper virus (PDV), and the cetacean viruses of dolphins and porpoises exhibit high levels of CNS infection in their natural hosts. CNS complications are rare for measles virus (MV) and are not associated with rinderpest virus (RPV) and peste des petits ruminants virus (PPRV) infection. However, it is possible that all morbilliviruses infect the CNS but in some hosts are rapidly cleared by the immune response. In this study, we assessed whether RPV and PPRV have the potential to be neurovirulent. We describe the outcome of infection, of selected mouse strains, with isolates of RPV, PPRV, PDV, porpoise morbillivirus (PMV), dolphin morbillivirus (DMV), and a wild-type strain of MV. In the case of RPV virus, strains with different passage histories have been examined. The results of experiments with these viruses were compared with those using neuroadapted and vaccine strains of MV, which acted as positive and negative controls respectively. Intracerebral inoculation with RPV (Saudi/81) and PPRV (Nigeria75/1) strains produced infection in Balb/C and Cd1, but not C57 suckling mice, whereas the CAM/RB rodent-adapted strain of MV infected all three strains of mice. Weanling mice were only infected by CAM/RB. Intranasal and intraperitoneal inoculation failed to produce infection with any virus strains. We have shown that, both RPV and PPRV, in common with other morbilliviruses are neurovirulent in a permissive system. Transient infection of the CNS of cattle and goats with RPV and PPRV, respectively, remains a possibility, which could provide relevant models for the initial stages of MV infection in humans.

AB - Members of the morbillivirus genus, canine distemper (CDV), phocine distemper virus (PDV), and the cetacean viruses of dolphins and porpoises exhibit high levels of CNS infection in their natural hosts. CNS complications are rare for measles virus (MV) and are not associated with rinderpest virus (RPV) and peste des petits ruminants virus (PPRV) infection. However, it is possible that all morbilliviruses infect the CNS but in some hosts are rapidly cleared by the immune response. In this study, we assessed whether RPV and PPRV have the potential to be neurovirulent. We describe the outcome of infection, of selected mouse strains, with isolates of RPV, PPRV, PDV, porpoise morbillivirus (PMV), dolphin morbillivirus (DMV), and a wild-type strain of MV. In the case of RPV virus, strains with different passage histories have been examined. The results of experiments with these viruses were compared with those using neuroadapted and vaccine strains of MV, which acted as positive and negative controls respectively. Intracerebral inoculation with RPV (Saudi/81) and PPRV (Nigeria75/1) strains produced infection in Balb/C and Cd1, but not C57 suckling mice, whereas the CAM/RB rodent-adapted strain of MV infected all three strains of mice. Weanling mice were only infected by CAM/RB. Intranasal and intraperitoneal inoculation failed to produce infection with any virus strains. We have shown that, both RPV and PPRV, in common with other morbilliviruses are neurovirulent in a permissive system. Transient infection of the CNS of cattle and goats with RPV and PPRV, respectively, remains a possibility, which could provide relevant models for the initial stages of MV infection in humans.

UR - http://www.scopus.com/inward/record.url?scp=0036185811&partnerID=8YFLogxK

U2 - 10.1080/135502802317247802

DO - 10.1080/135502802317247802

M3 - Article

VL - 8(1)

SP - 45

EP - 52

JO - Journal of Neurovirology

JF - Journal of Neurovirology

SN - 1355-0284

IS - 1

ER -