Risk factors related to inflammation and endothelial dysfunction in the DCCT/EDIC cohort and their relationship with nephropathy and macrovascular complications

Maria F Lopes-Virella, Rickey E Carter, Gregory E Gilbert, Richard L Klein, Miran Jaffa, Alicia J Jenkins, Timothy J Lyons, W Timothy Garvey, Gabriel Virella, Diabetes Control and Complications Trial/Epidemiology of Diabetes Intervention and Complications Cohort Study Group

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Because endothelial cell dysfunction and inflammation are key contributors to the development of complications in type 1 diabetes, we studied risk factors related to endothelial dysfunction and inflammation (C-reactive protein and fibrinogen, soluble vascular cell adhesion molecule-1, intracellular adhesion molecule-1, and E-selectin, and fibrinolytic markers) in a subgroup of patients from the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Intervention and Complications (EDIC) study cohort.
Original languageEnglish
Pages (from-to)2006-12
Number of pages7
JournalDiabetes Care
Volume31
Issue number10
DOIs
Publication statusPublished - Oct 2008

Keywords

  • Adult
  • Albuminuria
  • Biological Markers
  • C-Reactive Protein
  • Carotid Arteries
  • Cohort Studies
  • Diabetes Mellitus, Type 1
  • Diabetic Angiopathies
  • Diabetic Nephropathies
  • Endothelium, Vascular
  • Female
  • Humans
  • Inflammation
  • Male
  • Middle Aged
  • Models, Statistical
  • Regression Analysis
  • Risk Factors
  • Tunica Intima
  • Tunica Media

Fingerprint Dive into the research topics of 'Risk factors related to inflammation and endothelial dysfunction in the DCCT/EDIC cohort and their relationship with nephropathy and macrovascular complications'. Together they form a unique fingerprint.

  • Cite this

    Lopes-Virella, M. F., Carter, R. E., Gilbert, G. E., Klein, R. L., Jaffa, M., Jenkins, A. J., Lyons, T. J., Garvey, W. T., Virella, G., & Diabetes Control and Complications Trial/Epidemiology of Diabetes Intervention and Complications Cohort Study Group (2008). Risk factors related to inflammation and endothelial dysfunction in the DCCT/EDIC cohort and their relationship with nephropathy and macrovascular complications. Diabetes Care, 31(10), 2006-12. https://doi.org/10.2337/dc08-0659