Risk factors related to inflammation and endothelial dysfunction in the DCCT/EDIC cohort and their relationship with nephropathy and macrovascular complications

Maria F Lopes-Virella; Rickey E Carter; Gregory E Gilbert; Richard L Klein; Miran Jaffa; Alicia J Jenkins; Timothy J Lyons; W Timothy Garvey; Gabriel Virella; Diabetes Control and Complications Trial/Epidemiology of Diabetes Intervention and Complications Cohort Study Group

doi:10.2337/dc08-0659

Risk factors related to inflammation and endothelial dysfunction in the DCCT/EDIC cohort and their relationship with nephropathy and macrovascular complications

Maria F Lopes-Virella, Rickey E Carter, Gregory E Gilbert, Richard L Klein, Miran Jaffa, Alicia J Jenkins, Timothy J Lyons, W Timothy Garvey, Gabriel Virella, Diabetes Control and Complications Trial/Epidemiology of Diabetes Intervention and Complications Cohort Study Group

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

86 Citations (Scopus)

Abstract

Because endothelial cell dysfunction and inflammation are key contributors to the development of complications in type 1 diabetes, we studied risk factors related to endothelial dysfunction and inflammation (C-reactive protein and fibrinogen, soluble vascular cell adhesion molecule-1, intracellular adhesion molecule-1, and E-selectin, and fibrinolytic markers) in a subgroup of patients from the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Intervention and Complications (EDIC) study cohort.

Original language	English
Pages (from-to)	2006-12
Number of pages	7
Journal	Diabetes Care
Volume	31
Issue number	10
DOIs	https://doi.org/10.2337/dc08-0659
Publication status	Published - Oct 2008

Keywords

Adult
Albuminuria
Biological Markers
C-Reactive Protein
Carotid Arteries
Cohort Studies
Diabetes Mellitus, Type 1
Diabetic Angiopathies
Diabetic Nephropathies
Endothelium, Vascular
Female
Humans
Inflammation
Male
Middle Aged
Models, Statistical
Regression Analysis
Risk Factors
Tunica Intima
Tunica Media

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2337/dc08-0659

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Lopes-Virella, M. F., Carter, R. E., Gilbert, G. E., Klein, R. L., Jaffa, M., Jenkins, A. J., Lyons, T. J., Garvey, W. T., Virella, G., & Diabetes Control and Complications Trial/Epidemiology of Diabetes Intervention and Complications Cohort Study Group (2008). Risk factors related to inflammation and endothelial dysfunction in the DCCT/EDIC cohort and their relationship with nephropathy and macrovascular complications. Diabetes Care, 31(10), 2006-12. https://doi.org/10.2337/dc08-0659

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title = "Risk factors related to inflammation and endothelial dysfunction in the DCCT/EDIC cohort and their relationship with nephropathy and macrovascular complications",

abstract = "Because endothelial cell dysfunction and inflammation are key contributors to the development of complications in type 1 diabetes, we studied risk factors related to endothelial dysfunction and inflammation (C-reactive protein and fibrinogen, soluble vascular cell adhesion molecule-1, intracellular adhesion molecule-1, and E-selectin, and fibrinolytic markers) in a subgroup of patients from the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Intervention and Complications (EDIC) study cohort.",

keywords = "Adult, Albuminuria, Biological Markers, C-Reactive Protein, Carotid Arteries, Cohort Studies, Diabetes Mellitus, Type 1, Diabetic Angiopathies, Diabetic Nephropathies, Endothelium, Vascular, Female, Humans, Inflammation, Male, Middle Aged, Models, Statistical, Regression Analysis, Risk Factors, Tunica Intima, Tunica Media",

author = "Lopes-Virella, {Maria F} and Carter, {Rickey E} and Gilbert, {Gregory E} and Klein, {Richard L} and Miran Jaffa and Jenkins, {Alicia J} and Lyons, {Timothy J} and Garvey, {W Timothy} and Gabriel Virella and {Diabetes Control and Complications Trial/Epidemiology of Diabetes Intervention and Complications Cohort Study Group}",

year = "2008",

month = oct,

doi = "10.2337/dc08-0659",

language = "English",

volume = "31",

pages = "2006--12",

journal = "Diabetes Care",

issn = "0149-5992",

publisher = "American Diabetes Association Inc.",

number = "10",

}

Lopes-Virella, MF, Carter, RE, Gilbert, GE, Klein, RL, Jaffa, M, Jenkins, AJ, Lyons, TJ, Garvey, WT, Virella, G & Diabetes Control and Complications Trial/Epidemiology of Diabetes Intervention and Complications Cohort Study Group 2008, 'Risk factors related to inflammation and endothelial dysfunction in the DCCT/EDIC cohort and their relationship with nephropathy and macrovascular complications', Diabetes Care, vol. 31, no. 10, pp. 2006-12. https://doi.org/10.2337/dc08-0659

TY - JOUR

T1 - Risk factors related to inflammation and endothelial dysfunction in the DCCT/EDIC cohort and their relationship with nephropathy and macrovascular complications

AU - Lopes-Virella, Maria F

AU - Carter, Rickey E

AU - Gilbert, Gregory E

AU - Klein, Richard L

AU - Jaffa, Miran

AU - Jenkins, Alicia J

AU - Lyons, Timothy J

AU - Garvey, W Timothy

AU - Virella, Gabriel

AU - Diabetes Control and Complications Trial/Epidemiology of Diabetes Intervention and Complications Cohort Study Group

PY - 2008/10

Y1 - 2008/10

N2 - Because endothelial cell dysfunction and inflammation are key contributors to the development of complications in type 1 diabetes, we studied risk factors related to endothelial dysfunction and inflammation (C-reactive protein and fibrinogen, soluble vascular cell adhesion molecule-1, intracellular adhesion molecule-1, and E-selectin, and fibrinolytic markers) in a subgroup of patients from the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Intervention and Complications (EDIC) study cohort.

AB - Because endothelial cell dysfunction and inflammation are key contributors to the development of complications in type 1 diabetes, we studied risk factors related to endothelial dysfunction and inflammation (C-reactive protein and fibrinogen, soluble vascular cell adhesion molecule-1, intracellular adhesion molecule-1, and E-selectin, and fibrinolytic markers) in a subgroup of patients from the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Intervention and Complications (EDIC) study cohort.

KW - Adult

KW - Albuminuria

KW - Biological Markers

KW - C-Reactive Protein

KW - Carotid Arteries

KW - Cohort Studies

KW - Diabetes Mellitus, Type 1

KW - Diabetic Angiopathies

KW - Diabetic Nephropathies

KW - Endothelium, Vascular

KW - Female

KW - Humans

KW - Inflammation

KW - Male

KW - Middle Aged

KW - Models, Statistical

KW - Regression Analysis

KW - Risk Factors

KW - Tunica Intima

KW - Tunica Media

U2 - 10.2337/dc08-0659

DO - 10.2337/dc08-0659

M3 - Article

C2 - 18628568

SN - 0149-5992

VL - 31

SP - 2006

EP - 2012

JO - Diabetes Care

JF - Diabetes Care

IS - 10

ER -

Risk factors related to inflammation and endothelial dysfunction in the DCCT/EDIC cohort and their relationship with nephropathy and macrovascular complications

Abstract

Keywords

UN SDGs

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