Risk of Malignant Progression in Barrett’s Esophagus Patients: Results from a Large Population-Based Study

Shivaram Bhat, Helen G. Coleman, Fouad Yousef, Brian T Johnston, Damian T. McManus, Anna T. Gavin, Liam J. Murray

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Abstract

Background: Barrett's esophagus (BE) is a premalignant lesion that predisposes to esophageal adenocarcinoma. However, the reported incidence of esophageal adenocarcinoma in patients with BE varies widely. We examined the risk of malignant progression in patients with BE using data from the Northern Ireland Barrett's esophagus Register (NIBR), one of the largest population-based registries of BE worldwide, which includes every adult diagnosed with BE in Northern Ireland between 1993 and 2005.

Subjects and Methods: We followed 8522 patients with BE, defined as columnar lined epithelium of the esophagus with or without specialized intestinal metaplasia (SIM), until the end of 2008. Patients with incident adenocarcinomas of the esophagus or gastric cardia or with high-grade dysplasia of the esophagus were identified by matching the NIBR with the Northern Ireland Cancer Registry, and deaths were identified by matching with records from the Registrar General's Office. Incidence of cancer outcomes or high-grade dysplasia was calculated as events per 100 person-years (% per year) of follow-up, and Cox proportional hazard models were used to determine incidence by age, sex, length of BE segment, presence of SIM, macroscopic BE, or low-grade dysplasia. All P values were from two-sided tests.

Results: After a mean of 7.0 years of follow-up, 79 patients were diagnosed with esophageal cancer, 16 with cancer of the gastric cardia, and 36 with high-grade dysplasia. In the entire cohort, incidence of esophageal or gastric cardia cancer or high-grade dysplasia combined was 0.22% per year (95% confidence interval [CI] = 0.19% to 0.26%). SIM was found in 46.0% of patients. In patients with SIM, the combined incidence was 0.38% per year (95% CI = 0.31 to 0.46%). The risk of cancer was statistically significantly elevated in patients with vs without SIM at index biopsy (0.38% per year vs 0.07% per year; hazard ratio [HR] = 3.54, 95% CI = 2.09 to 6.00, P <. 001), in men compared with women (0.28% per year vs 0.13% per year; HR = 2.11, 95% CI = 1.41 to 3.16, P <. 001), and in patients with low-grade dysplasia compared with no dysplasia (1.40% per year vs 0.17% per year; HR = 5.67, 95% CI = 3.77 to 8.53, P <. 001).

Conclusion: We found the risk of malignant progression among patients with BE to be lower than previously reported, suggesting that currently recommended surveillance strategies may not be cost-effective. © The Author 2011. Published by Oxford University Press. All rights reserved.
Original languageEnglish
Pages (from-to)1049-1057
Number of pages9
JournalJournal of the National Cancer Institute
Volume103
Issue number13
Early online date16 Jun 2011
DOIs
Publication statusPublished - 06 Jul 2011

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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  • Impacts

    Re-assessment of Cancer risk in Barrett’s oesophagus.

    Fouad Yousef (Participant), Christopher Cardwell (Participant), Marie Cantwell (Participant), Karen Galway (Participant), Liam Murray (Participant), Lesley Anderson (Participant), Suzanne Murphy (Participant), Deirdre Fitzpatrick (Participant), Brian Johnston (Participant), Robert Watson (Participant), Peter McCarron (Participant), Anna Gavin (Participant), Shivaram Bhat (Participant), Helen Coleman (Participant), Damian McManus (Participant) & Helen Coleman (Participant)

    Impact: Health Impact, Quality of Life Impact

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