RNA-binding proteins: emerging therapeutics for vascular dysfunction

Victoria A. Cornelius, Hojjat Naderi-Meshkin, Sophia Kelaini, Andriana Margariti*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)
107 Downloads (Pure)

Abstract

Vascular diseases account for a significant number of deaths worldwide, with cardiovascular diseases remaining the leading cause of mortality. This ongoing, ever-increasing burden has made the need for an effective treatment strategy a global priority. Recent advances in regenerative medicine, largely the derivation and use of induced pluripotent stem cell (iPSC) technologies as disease models, have provided powerful tools to study the different cell types that comprise the vascular system, allowing for a greater understanding of the molecular mechanisms behind vascular health. iPSC disease models consequently offer an exciting strategy to deepen our understanding of disease as well as develop new therapeutic avenues with clinical translation. Both transcriptional and post-transcriptional mechanisms are widely accepted to have fundamental roles in orchestrating responses to vascular damage. Recently, iPSC technologies have increased our understanding of RNA-binding proteins (RBPs) in controlling gene expression and cellular functions, providing an insight into the onset and progression of vascular dysfunction. Revelations of such roles within vascular disease states have therefore allowed for a greater clarification of disease mechanisms, aiding the development of novel therapeutic interventions. Here, we discuss newly discovered roles of RBPs within the cardio-vasculature aided by iPSC technologies, as well as examine their therapeutic potential, with a particular focus on the Quaking family of isoforms.

Original languageEnglish
Article number2494
Number of pages16
JournalCells
Volume11
Issue number16
DOIs
Publication statusPublished - 11 Aug 2022

Keywords

  • Humans
  • Cardiovascular Diseases - metabolism
  • Induced Pluripotent Stem Cells - metabolism
  • QKI
  • stem cell technologies
  • RNA-binding proteins
  • Regenerative Medicine
  • RNA-Binding Proteins - metabolism
  • Quaking
  • iPSCs
  • vascular disease

Fingerprint

Dive into the research topics of 'RNA-binding proteins: emerging therapeutics for vascular dysfunction'. Together they form a unique fingerprint.

Cite this