RNA expression analysis from formalin fixed paraffin embedded tissues

S.M. Farragher, A. Tanney, Richard Kennedy, Paul Harkin

Research output: Contribution to journalArticle

149 Citations (Scopus)

Abstract

Formalin fixation and paraffin embedding (FFPE) is the most commonly used method worldwide for tissue storage. This method preserves the tissue integrity but causes extensive damage to nucleic acids stored within the tissue. As methods for measuring gene expression such as RT-PCR and microarray are adopted into clinical practice there is an increasing necessity to access the wealth of information locked in the Formalin fixation and paraffin embedding archives. This paper reviews the progress in this field and discusses the unique opportunities that exist for the application of these techniques in the development of personalized medicine.
Original languageEnglish
Pages (from-to)435-445
Number of pages11
JournalHistochemistry and Cell Biology
Volume130
Issue number3
DOIs
Publication statusPublished - Sep 2008

ASJC Scopus subject areas

  • Cell Biology
  • Instrumentation

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