Roadmap for precision preclinical x-ray radiation studies

Frank Verhaegen, Karl T. Butterworth, Anthony J. Chalmers, Rob P. Coppes, Dirk de Ruysscher, Sophie Dobiasch, John D. Fenwick, Patrick V. Granton, Stefan H.J. Heijmans, Mark A. Hill, Constantinos Koumenis, Kirsten Lauber, Brian Marples, Katia Parodi, Lucas C.G.G. Persoon, Nick Staut, Anna Subiel, Rianne D.W. Vaes, Stefan van Hoof, Ioannis L. VerginadisJan J. Wilkens, Kaye J. Williams, George D. Wilson

Research output: Contribution to journalReview articlepeer-review

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This Roadmap paper covers the field of precision preclinical x-ray radiation studies in animal models. It is mostly focused on models for cancer and normal tissue response to radiation, but also discusses other disease models. The recent technological evolution in imaging, irradiation, dosimetry and monitoring that have empowered these kinds of studies is discussed, and many developments in the near future are outlined. Finally, clinical translation and reverse translation are discussed.

Original languageEnglish
Article number06RM01
JournalPhysics in Medicine and Biology
Issue number6
Publication statusPublished - 31 Mar 2023

Bibliographical note

Publisher Copyright:
Creative Commons Attribution license.


  • translation
  • irradiation
  • cancer models
  • dosimetry
  • preclinical
  • precision
  • imaging

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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