Roadmap for precision preclinical x-ray radiation studies

Frank Verhaegen; Karl T. Butterworth; Anthony J. Chalmers; Rob P. Coppes; Dirk de Ruysscher; Sophie Dobiasch; John D. Fenwick; Patrick V. Granton; Stefan H.J. Heijmans; Mark A. Hill; Constantinos Koumenis; Kirsten Lauber; Brian Marples; Katia Parodi; Lucas C.G.G. Persoon; Nick Staut; Anna Subiel; Rianne D.W. Vaes; Stefan van Hoof; Ioannis L. Verginadis; Jan J. Wilkens; Kaye J. Williams; George D. Wilson

doi:10.1088/1361-6560/acaf45

Roadmap for precision preclinical x-ray radiation studies

Frank Verhaegen
, Karl T. Butterworth
, Anthony J. Chalmers
, Rob P. Coppes
, Dirk de Ruysscher
, Sophie Dobiasch
, John D. Fenwick
, Patrick V. Granton
, Stefan H.J. Heijmans
, Mark A. Hill
, Constantinos Koumenis
, Kirsten Lauber
, Brian Marples
, Katia Parodi
, Lucas C.G.G. Persoon
, Nick Staut
, Anna Subiel
, Rianne D.W. Vaes
, Stefan van Hoof
, Ioannis L. Verginadis

Jan J. Wilkens, Kaye J. Williams, George D. Wilson

Research output: Contribution to journal › Review article › peer-review

24 Citations (Scopus)

130 Downloads (Pure)

Abstract

This Roadmap paper covers the field of precision preclinical x-ray radiation studies in animal models. It is mostly focused on models for cancer and normal tissue response to radiation, but also discusses other disease models. The recent technological evolution in imaging, irradiation, dosimetry and monitoring that have empowered these kinds of studies is discussed, and many developments in the near future are outlined. Finally, clinical translation and reverse translation are discussed.

Original language	English
Article number	06RM01
Journal	Physics in Medicine and Biology
Volume	68
Issue number	6
DOIs	https://doi.org/10.1088/1361-6560/acaf45
Publication status	Published - 31 Mar 2023

Bibliographical note

Publisher Copyright:
Creative Commons Attribution license.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

translation
irradiation
cancer models
dosimetry
preclinical
precision
imaging

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging

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10.1088/1361-6560/acaf45Licence: CC BY

Roadmap for precision preclinical x-ray radiation studies
Copyright 2023 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 2.7 MBLicence: CC BY

Cite this

Verhaegen, F., Butterworth, K. T., Chalmers, A. J., Coppes, R. P., de Ruysscher, D., Dobiasch, S., Fenwick, J. D., Granton, P. V., Heijmans, S. H. J., Hill, M. A., Koumenis, C., Lauber, K., Marples, B., Parodi, K., Persoon, L. C. G. G., Staut, N., Subiel, A., Vaes, R. D. W., van Hoof, S., ... Wilson, G. D. (2023). Roadmap for precision preclinical x-ray radiation studies. Physics in Medicine and Biology, 68(6), Article 06RM01. https://doi.org/10.1088/1361-6560/acaf45

@article{1fcdd35150184303b8c1d50e5daf1b7e,

title = "Roadmap for precision preclinical x-ray radiation studies",

abstract = "This Roadmap paper covers the field of precision preclinical x-ray radiation studies in animal models. It is mostly focused on models for cancer and normal tissue response to radiation, but also discusses other disease models. The recent technological evolution in imaging, irradiation, dosimetry and monitoring that have empowered these kinds of studies is discussed, and many developments in the near future are outlined. Finally, clinical translation and reverse translation are discussed.",

keywords = "translation, irradiation, cancer models, dosimetry, preclinical, precision, imaging",

author = "Frank Verhaegen and Butterworth, \{Karl T.\} and Chalmers, \{Anthony J.\} and Coppes, \{Rob P.\} and \{de Ruysscher\}, Dirk and Sophie Dobiasch and Fenwick, \{John D.\} and Granton, \{Patrick V.\} and Heijmans, \{Stefan H.J.\} and Hill, \{Mark A.\} and Constantinos Koumenis and Kirsten Lauber and Brian Marples and Katia Parodi and Persoon, \{Lucas C.G.G.\} and Nick Staut and Anna Subiel and Vaes, \{Rianne D.W.\} and \{van Hoof\}, Stefan and Verginadis, \{Ioannis L.\} and Wilkens, \{Jan J.\} and Williams, \{Kaye J.\} and Wilson, \{George D.\}",

note = "Publisher Copyright: Creative Commons Attribution license.",

year = "2023",

month = mar,

day = "31",

doi = "10.1088/1361-6560/acaf45",

language = "English",

volume = "68",

journal = "Physics in Medicine and Biology",

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Verhaegen, F, Butterworth, KT, Chalmers, AJ, Coppes, RP, de Ruysscher, D, Dobiasch, S, Fenwick, JD, Granton, PV, Heijmans, SHJ, Hill, MA, Koumenis, C, Lauber, K, Marples, B, Parodi, K, Persoon, LCGG, Staut, N, Subiel, A, Vaes, RDW, van Hoof, S, Verginadis, IL, Wilkens, JJ, Williams, KJ & Wilson, GD 2023, 'Roadmap for precision preclinical x-ray radiation studies', Physics in Medicine and Biology, vol. 68, no. 6, 06RM01. https://doi.org/10.1088/1361-6560/acaf45

TY - JOUR

T1 - Roadmap for precision preclinical x-ray radiation studies

AU - Verhaegen, Frank

AU - Butterworth, Karl T.

AU - Chalmers, Anthony J.

AU - Coppes, Rob P.

AU - de Ruysscher, Dirk

AU - Dobiasch, Sophie

AU - Fenwick, John D.

AU - Granton, Patrick V.

AU - Heijmans, Stefan H.J.

AU - Hill, Mark A.

AU - Koumenis, Constantinos

AU - Lauber, Kirsten

AU - Marples, Brian

AU - Parodi, Katia

AU - Persoon, Lucas C.G.G.

AU - Staut, Nick

AU - Subiel, Anna

AU - Vaes, Rianne D.W.

AU - van Hoof, Stefan

AU - Verginadis, Ioannis L.

AU - Wilkens, Jan J.

AU - Williams, Kaye J.

AU - Wilson, George D.

N1 - Publisher Copyright: Creative Commons Attribution license.

PY - 2023/3/31

Y1 - 2023/3/31

N2 - This Roadmap paper covers the field of precision preclinical x-ray radiation studies in animal models. It is mostly focused on models for cancer and normal tissue response to radiation, but also discusses other disease models. The recent technological evolution in imaging, irradiation, dosimetry and monitoring that have empowered these kinds of studies is discussed, and many developments in the near future are outlined. Finally, clinical translation and reverse translation are discussed.

AB - This Roadmap paper covers the field of precision preclinical x-ray radiation studies in animal models. It is mostly focused on models for cancer and normal tissue response to radiation, but also discusses other disease models. The recent technological evolution in imaging, irradiation, dosimetry and monitoring that have empowered these kinds of studies is discussed, and many developments in the near future are outlined. Finally, clinical translation and reverse translation are discussed.

KW - translation

KW - irradiation

KW - cancer models

KW - dosimetry

KW - preclinical

KW - precision

KW - imaging

U2 - 10.1088/1361-6560/acaf45

DO - 10.1088/1361-6560/acaf45

M3 - Review article

C2 - 36584393

SN - 0031-9155

VL - 68

JO - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

IS - 6

M1 - 06RM01

ER -

Roadmap for precision preclinical x-ray radiation studies

Abstract

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

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