Role played by BRCA1 in transcriptional regulation in response to therapy

M. M. Murray, P. B. Mullan, D.P. Harkin

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

BRCA1 (breast-cancer susceptibility gene 1) is a tumour suppressor, implicated in the hereditary predisposition to breast and ovarian cancer. BRCA1 has been implicated in a number of cellular processes including DNA repair and recombination, cell cycle checkpoint control, chromatin remodelling and ubiquitination. In addition, substantial data now exist to suggest a role for BRCA1 in transcriptional regulation; BRCA1 has been shown to interact with the Pol II holoenzyme complex and to interact with multiple transcription factors, such as p53 and c-Myc. We have previously identified a range of BRCA1 transcriptional targets and have linked these to specific cellular pathways, including cell cycle checkpoint activation and apoptosis. Current research is focused on the transcriptional mechanisms that underpin the association of BRCA1 deficiency with increased sensitivity to DNA damage-based chemotherapy and resistance to spindle poisons.
Original languageEnglish
Pages (from-to)1342-1346
Number of pages5
JournalBiochemical society transactions
Volume35
Issue number5
DOIs
Publication statusPublished - Nov 2007

Keywords

  • Breast-cancer susceptibility gene 1 (brca1)
  • Cell cycle
  • Checkpoint
  • Chemotherapy
  • Transcription

ASJC Scopus subject areas

  • Biochemistry

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