Routine molecular subgrouping of medulloblastoma: Bridging the divide between research and the clinic using low-cost, mass spectrometry-based DNA methylomics

E.C. Schwalbe, H. Gohlke, D. Hicks, Gholamreza Rafiee, A Enshaei, S. Potluri, J. Matthiesen, M. Mather, R Chaston, S. Crosier, A. J. Smith, D. Williamson, S. Bailey, S.C. Clifford

Research output: Other contribution

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Abstract

DNA-methylation patterns allow the subclassification of medulloblastoma, the most common childhood malignant brain tumour, into four molecular subgroups (WNT, SHH, MBGrp3 and MBGrp4). These subgroups have distinct molecular and clinico-pathological features, and their distinction is now informing future treatments and risk-stratification. Whilst microarrays to assign subgroup are suitable for research purposes, they are limited by expense, platform-specificity, sample quality requirements and practicality. Here, we aimed to develop a low-cost, array-independent, robust subgrouping assay suitable for routine quality-controlled subclassification, including scant and poor-quality samples.
Original languageEnglish
TypeNational Cancer Research Institute (NCRI)
Media of outputAbstract
PublisherNational Cancer Research Institute (NCRI)
Publication statusPublished - 2014

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