RUNX3 functions as an oncogene in ovarian cancer

Cecilia Wei Lin Lee, Linda Shyue Huey Chuang, Shunichi Kimura, Soak Kuan Lai, Chee Wee Ong, Benedict Yan, Manuel Salto-Tellez, Mahesh Choolani, Yoshiaki Ito

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43 Citations (Scopus)

Abstract

The Runt domain transcription factor, RUNX3, has been shown to be a tumor suppressor in a variety of cancers including gastric, colon and breast cancer. Interestingly, an oncogenic role for RUNX3 has also been suggested in basal cell carcinoma and head and neck cancer. Here, we explore the role of RUNX3 in ovarian cancer.
Original languageEnglish
Pages (from-to)410-7
Number of pages8
JournalGynecologic Oncology
Volume122
Issue number2
DOIs
Publication statusPublished - Aug 2011

Bibliographical note

Copyright © 2011 Elsevier Inc. All rights reserved.

Keywords

  • Gene Expression Profiling
  • Ovarian Neoplasms
  • Oncogenes
  • Humans
  • Core Binding Factor Alpha 3 Subunit
  • Cell Line, Tumor
  • Female

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  • Cite this

    Lee, C. W. L., Chuang, L. S. H., Kimura, S., Lai, S. K., Ong, C. W., Yan, B., Salto-Tellez, M., Choolani, M., & Ito, Y. (2011). RUNX3 functions as an oncogene in ovarian cancer. Gynecologic Oncology, 122(2), 410-7. https://doi.org/10.1016/j.ygyno.2011.04.044