Safety, pharmacokinetic, and functional effects of the Nogo-A monoclonal antibody in amyotrophic lateral sclerosis: a randomized, first-in-human clinical trial

Hiroyoshi Nishikawa; Vincent Meininger; Pierre-François Pradat; Andrea Corse; Safa Al-Sarraj; Benjamin Rix Brooks; James B. Caress; Merit Cudkowicz; Stephen J. Kolb; Dale Lange; P. Nigel Leigh; Thomas Meyer; Stefano Milleri; Karen E. Morrison; Richard W. Orrell; Gary Peters; Jeffrey D. Rothstein; Jeremy Shefner; Arseniy Lavrov; Nicola Williams; Phil Overend; Jeffrey Price; Stewart Bates; Jonathan Bullman; David Krull; Alienor Berges; Bams Abila; Guy Meno-Tetang; Jens Wurthner

doi:10.1371/journal.pone.0097803

Safety, pharmacokinetic, and functional effects of the Nogo-A monoclonal antibody in amyotrophic lateral sclerosis: a randomized, first-in-human clinical trial

Hiroyoshi Nishikawa, Vincent Meininger, Pierre-François Pradat, Andrea Corse, Safa Al-Sarraj, Benjamin Rix Brooks, James B. Caress, Merit Cudkowicz, Stephen J. Kolb, Dale Lange, P. Nigel Leigh, Thomas Meyer, Stefano Milleri, Karen E. Morrison, Richard W. Orrell, Gary Peters, Jeffrey D. Rothstein, Jeremy Shefner, Arseniy Lavrov, Nicola WilliamsPhil Overend, Jeffrey Price, Stewart Bates, Jonathan Bullman, David Krull, Alienor Berges, Bams Abila, Guy Meno-Tetang, Jens Wurthner

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Original language	English
Pages (from-to)	1-12
Number of pages	12
Journal	PLoS ONE
Volume	9
Issue number	5
DOIs	https://doi.org/10.1371/journal.pone.0097803
Publication status	Published - 19 May 2014

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Nishikawa, H., Meininger, V., Pradat, P.-F., Corse, A., Al-Sarraj, S., Rix Brooks, B., Caress, J. B., Cudkowicz, M., Kolb, S. J., Lange, D., Leigh, P. N., Meyer, T., Milleri, S., Morrison, K. E., Orrell, R. W., Peters, G., Rothstein, J. D., Shefner, J., Lavrov, A., ... Wurthner, J. (2014). Safety, pharmacokinetic, and functional effects of the Nogo-A monoclonal antibody in amyotrophic lateral sclerosis: a randomized, first-in-human clinical trial. PLoS ONE, 9(5), 1-12. https://doi.org/10.1371/journal.pone.0097803

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author = "Hiroyoshi Nishikawa and Vincent Meininger and Pierre-Fran{\c c}ois Pradat and Andrea Corse and Safa Al-Sarraj and {Rix Brooks}, Benjamin and Caress, {James B.} and Merit Cudkowicz and Kolb, {Stephen J.} and Dale Lange and Leigh, {P. Nigel} and Thomas Meyer and Stefano Milleri and Morrison, {Karen E.} and Orrell, {Richard W.} and Gary Peters and Rothstein, {Jeffrey D.} and Jeremy Shefner and Arseniy Lavrov and Nicola Williams and Phil Overend and Jeffrey Price and Stewart Bates and Jonathan Bullman and David Krull and Alienor Berges and Bams Abila and Guy Meno-Tetang and Jens Wurthner",

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Nishikawa, H, Meininger, V, Pradat, P-F, Corse, A, Al-Sarraj, S, Rix Brooks, B, Caress, JB, Cudkowicz, M, Kolb, SJ, Lange, D, Leigh, PN, Meyer, T, Milleri, S, Morrison, KE, Orrell, RW, Peters, G, Rothstein, JD, Shefner, J, Lavrov, A, Williams, N, Overend, P, Price, J, Bates, S, Bullman, J, Krull, D, Berges, A, Abila, B, Meno-Tetang, G & Wurthner, J 2014, 'Safety, pharmacokinetic, and functional effects of the Nogo-A monoclonal antibody in amyotrophic lateral sclerosis: a randomized, first-in-human clinical trial', PLoS ONE, vol. 9, no. 5, pp. 1-12. https://doi.org/10.1371/journal.pone.0097803

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AU - Nishikawa, Hiroyoshi

AU - Meininger, Vincent

AU - Pradat, Pierre-François

AU - Corse, Andrea

AU - Al-Sarraj, Safa

AU - Rix Brooks, Benjamin

AU - Caress, James B.

AU - Cudkowicz, Merit

AU - Kolb, Stephen J.

AU - Lange, Dale

AU - Leigh, P. Nigel

AU - Meyer, Thomas

AU - Milleri, Stefano

AU - Morrison, Karen E.

AU - Orrell, Richard W.

AU - Peters, Gary

AU - Rothstein, Jeffrey D.

AU - Shefner, Jeremy

AU - Lavrov, Arseniy

AU - Williams, Nicola

AU - Overend, Phil

AU - Price, Jeffrey

AU - Bates, Stewart

AU - Bullman, Jonathan

AU - Krull, David

AU - Berges, Alienor

AU - Abila, Bams

AU - Meno-Tetang, Guy

AU - Wurthner, Jens

PY - 2014/5/19

Y1 - 2014/5/19

U2 - 10.1371/journal.pone.0097803

DO - 10.1371/journal.pone.0097803

M3 - Article

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VL - 9

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JO - PLoS ONE

JF - PLoS ONE

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