Scaling of continuous twin screw wet granulation

Juan G. Osorio, Ridade Sayin, Arjun V. Kalbag, James D. Litster*, Laura Martinez-Marcos, Dimitrios A. Lamprou, Gavin W. Halbert

*Corresponding author for this work

Research output: Contribution to journalArticle

12 Citations (Scopus)
314 Downloads (Pure)

Abstract

Scaling rules were developed and tested for a continuous twin screw wet granulation process using three scales (11, 16, and 24 mm barrel diameter) of twin screw granulators (TSG). The distributive feed screw configuration used produced high porosity granules (50–60%) with broad bimodal size distributions, especially in the 16 and 24 mm TSGs. Three dimensionless numbers, Froude number (Fr), liquid-to-solid ratio (LSR), and powder feed number (PFN), were identified and their effect on granule size distribution (GSD), porosity and liquid distribution tested. Granule size increased with increasing LSR as expected. However, Fr and PFN had no significant effect on d10or d50and only a small effect on d90. In contrast, granulator scale had a strong effect on GSD, with d90increasing almost linearly with barrel diameter. This is consistent with breakage of large granules being a dominant mechanism and directly controlled by the geometry of the screw.

Original languageEnglish
Pages (from-to)921-932
JournalAIChE Journal
Volume63
Issue number3
Early online date14 Sep 2016
DOIs
Publication statusPublished - 03 Feb 2017
Externally publishedYes

Keywords

  • continuous manufacturing
  • powders
  • scaling
  • twin screw granulation

ASJC Scopus subject areas

  • Biotechnology
  • Environmental Engineering
  • Chemical Engineering(all)

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