Abstract
Hepatic fibrosis is a common pathology in various liver diseases. Hepatic stellate cells (HSCs) are the main cell type responsible for collagen deposition and fibrosis formation in the liver. Schistosomiasis is characterised by granulomatous fibrosis around parasite eggs trapped within the liver and other host tissues. This response is facilitated by the recruitment of immune cells and the activation of HSCs. The interactions between HSCs and schistosome eggs are complex and diverse, and a better understanding of these interactions could lead to improved resolution of fibrotic liver disease, including that associated with schistosomiasis. Here, we discuss recent advances in HSC biology and the role of HSCs in hepatic schistosomiasis.
Original language | English |
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Number of pages | 17 |
Journal | Trends in Parasitology |
Early online date | 08 Mar 2018 |
DOIs | |
Publication status | Early online date - 08 Mar 2018 |
Keywords
- collagen
- fibrosis
- hepatic stellate cell
- Schistosoma
- schistosomiasis
ASJC Scopus subject areas
- Parasitology
- Infectious Diseases
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Dive into the research topics of 'Schistosome-Induced Fibrotic Disease: The Role of Hepatic Stellate Cells'. Together they form a unique fingerprint.Student theses
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Exploring the interactions between schistosome eggs and the human host
Carson, J. (Author), Gobert, G. (Supervisor) & Robinson, M. (Supervisor), Jul 2021Student thesis: Doctoral Thesis › Doctor of Philosophy
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